Özet:

The obese population has been rapidly increasing because of high-fat consumption and a sedentary lifestyle. Large amounts of dietary fat intake increase the risk of cardiovascular disease. We aimed to investigate the effects of exercise and obestatin on a high-fat diet (HFD) induced cardiac hemodynamic changes. Seventy-nine Sprague-Dawley rats (200 to 250 g) were fed either control diet or HFD for 8 weeks. In the 5th week, each diet group was subgrouped as follows; control, exercise, obestatin (25μg/kg, i.p), exercise+obestatin (25μg/kg, i.p). After the end of 4 weeks of exercise (swimming exercise, 5 days a week/ 20 min day) and obestatin administration period, all animals were sacrificed. Hearts were removed for hemodynamic measurements with the Langendorff apparatus. Blood samples were collected for biochemical measurements. Data were analyzed by Graphpad Prism 6.0. and p<0.05 was accepted as statistically significant. Cardiac contractility and hemodynamic parameters in the HFD model have been evaluated. And the effects of chronic obestatin treatment and exercise were studied together. Obestatin ameliorated derangements in LVDP, heart rate, and blood lipid levels induced by an HFD. Also, obestatin prevents decreasing BNP levels with high-fat consumption. Obestatin treatment potentiated the beneficial effects of exercise evidenced by LVDP, heart rate, blood lipids, BNP, and AT2R1 measurements. We believe that obestatin has the potential for the maintenance of cardiac function in HFD.

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