Abstract:

This study was conducted with the aim of investigating the effects of manganese chloride (MnCl2) on liver and kidney arginase in high doses of gentamisin. Adults 36 Wistar Albino rat 6 were divided into equal groups. First group control, second group gentamisin alone (gentamisin sulfate 100 mg/kg, i.p.MnCl2 alone to the third and fourth groups (secondly, 2 and 20 mg/kg, i.p.The fifth and sixth groups were given two different doses of MnCl2 along with gentamisin for 6 days. In the liver and kidney samples taken 24 hours after the last injection, arginase activity was determined by a spectrophotometric method. The activity of the liver and kidney tissue arginase compared to the control group, gentamisin increased in the given groups. The low dose of MnCl2 increases the activity of arginase in the liver according to control (p<0.001), while the high dose does not change the activity (p>0.05). In contrast, MnCl2 in the kidneys was found to increase both low and high doses of arginase activity (p<0.001). MnCl2, given with Gentamisin, increased the activity of arginase in both the liver and the kidneys. Low doses of MnCl2, administered in the liver along with gentamisine, increased arginase activity (p<0.001), more than high doses of MnCl2 (p<0.001). As a result, it was found that low quantities of manganese in terms of reducing the damage caused during the high doses of gentamisin was found to help heal by increasing arginase activity.

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