Özet:

Objective: In this study we aimed to investigate the relationship between insulin resistance and pre-diabetic patients’ serum resistin levels, inflammatory and oxidative stress parameters that take part in the progress of type 2 diabetes mellitus (DM). Resistin is a newly discovered adipokine which is secreted from adipose tissue that has important roles in the pathogenesis of obesity mediated-insulin resistance. Methods: 59 adult patients who applied to the internal medicine out patient clinic were enrolled to the study [41 IFG (impaired fasting glucose), 18 IFG+IGT (impaired fasting glucose+impaired gluose tolerance)]. Routine biochemical and haematological parameters were calculated by autoanalyzers. Serum resistin levels were measured by ELISA procedure. Statistical analyses were performed by SPSS for Windows. Results: Resistin levels in IFG and IFG+IGT groups were significantly higher compared to control group. A positive correlation were detected between serum resistin levels and age, FPG, HbA1C, Homa-IR, oral glucose tolerance test (OGTT) 0. hour, OGTT 2. hour also, there were a negative correlation between serum resistin levels and high-density lipoprotein. Conclusion: The onset or progression of diabetes could be slowed down by interveining the metabolic and modifiable parameters in prediabetic patients who have high risk of developing diabetes.

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