Özet:

60 females patients in ASA I-II groups under going total abdominal hysterectomy, randomized into 3 groups and premedicated orally with 5 mg/kg clonidine, 0.1 mg/kg diazepam and 20 mg famotidine tablets respectively. 10-points visual analoge scale (VAS) was recorded before and after premedication. During anesthesia induction, after 60 sec later of 2 mg/kg fentanyl administration, propofol was given till the lost of eyelash reflex and cooperation in all patients. Endotracheal entubation was provided by 0.1 mg/kg vecuronium. İn maintenance of anesthesia, 100 mg/kg propofol and 50 % N2O-O2 was used. Blood samples for glucose, cortisole and lactate levels were collected before premedication, 30. min of surgical incision and 60 min of postoperative period. Haemodynamic parameters were recorded before premedication and 5 min intervals after premedication and during surgical period. After premedication, VAS score declines were statistically significant in Group I and II compared to Group III (p<0.05) but in Group II, VAS scores were significantly less than group III (p<0.001). Anesthetic requirements were significantly less in group I (p<0.01). Blood glucose levels were significantly high related to basal values in Group II and III (p<0.05) but the differences were not significant between these three groups (p>0.05). Blood cortisole levels were significantly high related to basal levels on 60 min of postoperative period in all groups (p<0.05). Rising of blood cortisole levels in Group I and II were significantly less compared to Group III (p<0.05). As a result, it’s concluded that clonidine could be a good alternative to oral diazepam in premedication because of the reducing anxiety, cost, stress response to endotracheal entubation and surgery beyond the haemodynamic stability.

Anahtar Kelimeler: