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Amaç: Hemodiyaliz (HD) uygulanan hastaların bağışıklık sistemindeki bozulmalar, hastaların enfeksiyon ajanlarına daha duyarlı olmasına neden olur. Bu çalışmanın amacı hemodiyaliz tedavisi gören hastalarda HBV, HCV ve HIV seroprevalansını belirlemek olmuştur. Gereç ve Yöntem: Selçuk Üniversitesi Tıp Fakültesin’de hemodiyaliz tedavisi gören Kronik Böbrek Hastalarının (KBH) serum örneklerinden çalışılmış HBsAg, Anti-HBs, Anti-HBc IgM, Anti-HBc IgG, HBV-DNA, Anti-HCV, HCV-.RNA ve Anti-HIV parametrleri on yıl boyunca retrospektif olarak taranmıştır. Bulgular: 4155 hemodiyaliz hastasının 17'sinde (% 0,40) HBsAg ve 454'ünde ise (% 11,2) Anti-HBs pozitif bulunmuştur. Anti-HCV 14 (% 0.33) hastanın serumunda pozitift olarak saptanmıştır. HBsAg pozitif HD hastalarının 13'ünde (% 76,5) HBV-DNA ve Anti-HCV pozitif hastaların 12'sinde (% 85,7) HCV RNA pozitift olarak belirlenmiştir. Serum örneklerinin hiçbirinde anti-HIV antikorları tespit edilmemiştir. Sonuç: Çalışma sonuçları, hemodiyaliz hastalarında uygun enfeksiyon kontrol önlemlerinin bulaşıcı ajanların kontaminasyonunu azaltabileceğini göstermiştir. Ayrıca, aşılama şeması, aşılama yeri ve doz gibi faktörler, hastaların immünosupresif durumu dikkate alınarak uygun şekilde seçilmelidir.
Purpose: Disorders in the immune system of patients with hemodialysis (HD) cause patients to be more sensitive to infectious agents. The aim of this study was to determine seroprevalence of HBV, HCV and HIV in patients treated with hemodialysis. Tools and Methods: The HBsAg, Anti-HBs, Anti-HBc IgM, Anti-HBc IgG, HBV-DNA, Anti-HCV, HCV-.RNA and Anti-HIV parameters studied from serum samples of chronic kidney patients (KBH) treated in the Faculty of Medicine of Selçuk have been scaned retrospectively for a decade. Results: 4155 patients with hemodialysis in 17 (% 0.40) had HBsAg and 454 (% 11.2) had anti-HBs positive. Anti-HCV 14 (% 0.33) was positively detected in the patient's serum. In 13 patients with HBsAg positive HD (76,5%) in 12 patients with HBV-DNA and Anti-HCV positive (85.7%) HCV RNA was determined as positive. No anti-HIV antibodies have been detected in any of the serum samples. Results: Study results have shown that appropriate infection control measures in hemodial patients can reduce the contamination of infectious agents. Furthermore, factors such as the vaccination scheme, the place of vaccination and the dose should be properly selected, taking into account the immune suppressive condition of patients.
Aim: Impairments in the immune system of patients undergoing HD cause patients to be more sensitive to infection agents. The purpose of this study; to determine the seroprevalance of HBV, HCV and HIV in patients undergoing hemodialysis treatment. Materials and Methods: HBsAg, Anti-HBs, Anti-HBc IgM, Anti-HBc IgG, HBV-DNA, Anti-HCV, HCV-RNA and Anti-HIV parameters studied from serum samples of Chronic Kidney Patients (CKD) undergoing hemodialysis treatment at Selçuk University Faculty of Medicine It has been scanned retrospectively for ten years. Results: HBsAg was determined in 17 (0.40%) of 4155 hemodialysis patients and Anti-HBs was positive in 454 (11.2%). Anti-HCV was detected as positive in 14 (0.33%) serum. HBV-DNA was found to be positive in 13 (76.5%) of HBsAg positive HD patients and in 12 (85.7%) of Anti-HCV positive patients. Anti-HIV antibodies were not detected in any of the serum samples. Conclusions: The results of our study have shown that proper infection control measures in hemodialysis patients can reduce the contamination of infectious agents. In addition, factors such as vaccination scheme, inoculation site and dose should be selected appropriately, taking into account the immunosuppressive state of the patients.
Alan : Sağlık Bilimleri
Dergi Türü : Uluslararası
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