Abstract The rapid advancement in pattern recognition via the deep learning method has made it possible to develop an autonomous medical image classification system. This system has proven robust and accurate in classifying most pathological features found in a medical image, such as airspace opacity, mass, and broken bone. Conventionally, this system takes routine medical images with minimum pre-processing as the model's input; in this research, we investigate if saliency maps can be an alternative model input. Recent research has shown that saliency maps' application increases deep learning model performance in image classification, object localization, and segmentation. However, conventional bottom-up saliency map algorithms regularly failed to localize salient or pathological anomalies in medical images. This failure is because most medical images are homogenous, lacking color, and contrast variant. Therefore, we also introduce the Xenafas algorithm in this paper. The algorithm creates a new kind of anomalous saliency map called the Intensity Probability Mapping and Weighted Intensity Probability Mapping. We tested the proposed saliency maps on five deep learning models based on common convolutional neural network architecture. The result of this experiment showed that using the proposed saliency map over regular radiograph chest images increases the sensitivity of most models in identifying images with air space opacities. Using the Grad-CAM algorithm, we showed how the proposed saliency map shifted the model attention to the relevant region in chest radiograph images. While in the qualitative study, it was found that the proposed saliency map regularly highlights anomalous features, including foreign objects and cardiomegaly. However, it is inconsistent in highlighting masses and nodules.
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