Özet:

Previous research indicate that serum leptin levels are highly correlated to obesity and obesityinduced disorders. Regular exercise has a reductive effect on obesity. Exercise affect the production and secretion of leptin. This positively contribesting to obesity and obesity-related diseases. We aimed to research the effect of regular physical activity and strenuous short-time exercise on serum leptin levels and the relationships between leptin and arterial pressure, nitric oxide (NO) and ventilation. The study consisted of four groups. 1. The two groups consisted of 15 female (grup 1) and 15 male (grup 2) who are regular exercise students. Other two groups were 15 female (grup 3) and 15 male (grup 4) students who lived sedentarily. Serum leptin levels, blood pressures and plasma nitric oxide levels were determined in four groups before and immediately after cessation of exercise and 30 minutes after the end of the exercise period. Respiratory parameters were determined in four groups during exercise period. The leptin levels were significantly different among the groups. Serum leptin levels and serum leptin levels/ body mass index rations were significantly different between female students who did regular exercise and those who did not. There were significant positive correlations in all students between serum leptin levels and height (r=0.259, p<0.001), heart rate (r=0.006, p<0.05) before exercise. There were significant positive correlation in all students between serum leptin levels and diastolic pressure (r=0.075, p<0.02), significant negative correlations between serum leptin levels and VO2(r=0.058, p<0.04), VO2 max (r=0.059, p<0.04). Physical activity has decreased serum leptin levels. In conclusion, serum leptin hormone may play an intermediary role in adapting the body systems to compliance with exercise

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