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Amaç: Bu çalışmanın amacı, Myastenia Gravis (MG) tanısı ile izlenen hastaların demografik özellikleri, ilk başvuru şikayeti ile klinik seyir, antikor ve elektrofizyolojik özelliklerini değerlendirmektir. Gereç ve Yöntem: 2014-2019 yılları arasında, hastanemiz Nöromusküler ve Kas Hastalıkları Polikliniği’nde takip edilen yüz otuz sekiz MG hastasının demografik özellikleri, ilk başvuru şikayeti ile klinik seyri, antikor, elektrofizyolojik ve radyolojik (toraks tomografi) özellikleri incelendi. Bulgular: Hastaların yaş ortalaması 53.8±16.67 idi. Ortalama hastalık süresi 4.8±5.05 yıl idi. Hastalarımızın en sık, ilk başvuru şikayeti %79 (n=109)’unda ptozis idi. Saf oküler MG olarak takip edilen hasta sayısı %61.6 (n=85) kişiydi. İlk başvurusunda ptozis veya diplopi şikayetiyle gelip, daha sonrasında bulber bulgular ve güçsüzlük eklenerek jeneralize MG düşünülen 26 hasta bulunuyordu. Hastaların %78.3 (n=108)’ünde asetil kolin reseptör antikoru (AntiAChRAb) pozitifliği ve %37.7 (n=52)’sinde toraks tomografide timüs patolojisi bulundu. Sonuç: İlk başvuru şikayeti hastalığın seyri hakkında çok az fikir vermektedir. Asıl önemli olan, klinik yakın takiptir. Her ne kadar MG tedavisi bilinse de MG’in patofizyolojisi halen tam olarak aydınlatılamamıştır ve diğer otoimmun durumlar tedavi seçiminde değişikliğe neden olmaktadır. MG patofizyolojisinin aydınlatılması, daha etkin tanı ve tedavi yöntemlerinin geliştirilmesini sağlayacaktır.
Purpose: The purpose of this study is to evaluate the demographic characteristics of the patients monitored with the diagnosis of Myastenia Gravis (MG), the clinical navigation, antibodies and electrophysiological characteristics with the first application complaint. Instruments and Methods: Between 2014-2019, the demographic characteristics of a hundred and thirty-eight MG patients followed in our Hospital's Neuromuscular and Muscular Diseases Clinic, the first application complaint and the clinical path, antibodies, electrophysiological and radiological (toractic tomography) characteristics were studied. The average age of patients was 53.8±16.67. The average duration of the disease was 4.8±5.05 years. Often, the first complaint of our patients was ptosis at 79% (n=109). The number of patients followed as pure ocular MG was 61.6% (n=85) people. In the first application, there were 26 patients who were considered to generalize MG with ptosis or diplopy complaints, and subsequently added bulb findings and weakness. In 78.3 percent of patients (n=108) acetyl choline receptor antibodies (AntiAChRAb) positive and in 37.7 percent (n=52) thorax tomography timus pathology was found. The result: The first application complaint gives very little idea about the course of the disease. The most important thing is the clinical follow-up. Although the treatment of MG is known, the pathophysology of MG is not yet fully illuminated and other autoimmune conditions cause changes in the choice of treatment. The illumination of MG pathophysology will help develop more effective diagnosis and treatment methods.
Aim: The aim of this study was to evaluate the demographic characteristics, clinical presentation, antibody, and electrophysiological characteristics of patients with the diagnosis of Myasthenia Gravis (MG). Materials and Methods: The demographic characteristics, clinical presentation, antibody, electrophysiological and radiological (thoracic tomography) characteristics of the patients who were followed in the Neuromuscular and Muscular Diseases Polyclinic of the hospital between 2014-2019 were analyzed. Results: The mean age of the patients was 53.8±16.67 years. The mean disease duration was 4.8±5.05 years. Ptosis was the most common complaint in 79% (n=109) of our patients. The number of patients followed as pure ocular MG was 61.6% (n=85). There were 26 patients who presented with ptosis or diplopia at the first presentation and follow-up generalized MG with bulbar findings and weakness. Acetylcholine receptor antibody (AntiAChRAb) positivity was found in 78.3% (n=108) of the patients and thymus pathology was detected in thorax tomography in 37.7% (n=52). Conclusions: The initial complaint provides little insight into the course of the disease. The important factor is clinical follow-up. Although MG treatment is known, the pathophysiology of MG remains to be elucidated, and other autoimmune conditions cause changes in treatment choice. Clarifying the pathophysiology of MG will enable the development of more effective diagnostic and treatment methods.
Field : Sağlık Bilimleri
Journal Type : Uluslararası
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