Abstract:

Goal: Idiopathic Parkinson's disease (PH) is a neurodegenerative disease seen in certain areas of the central nervous system with progressive loss of neurons. To reduce the effects of free radicals, which play a role in the etiology of many neurodegenerative diseases, and to eliminate the damage they create; organisms have developed complex antioxidant systems. In Parkinson's disease, oxidative stress is believed to play a pathophysical role. This study aims to investigate the role and the relationship of dynamic thyol-disulfide homeostasis as an oxidative stress indicator in PH pathophysology with the characteristics of the disease. Material and Method: This study was done with 36 PH and 22 healthy controls. The total thyol (TT) (μmol/L) and Native thyol (NT) (μmol/L) measurements in the serum have made a comprehensive measurement of the thyols and the thyol/disulfide balance, which is a new oxidative indicator, has been detected. Results: NT levels were found lower in the patient group (p<0,05). NT and TT levels were determined in relation to the UPDRS scores and the TT level with the H-Y stage (-) (p<0,05). The result: With these findings that suggest that thyol-disulfide homeostasis is deteriorated in the favor of the oxidative process, the importance of this mechanism in PH pathophysology and progress can be emphasized