Özet:

This study was conducted to determine the effects of medetomidine-ketamine-atipamezole anaesthesia protocol on haematologic and biochemical parameters of dogs, and to evalute the use of this anaestesia protocol in small animal practice in the light of the obtained findings. In this experimental study, 12 dogs, weighing 33.2±3.30 kg., were used. Medetomidine (Domitor®, Pfizer®, Finland), at a dose of 30 µg/kg, was administrated via im route to the dogs following 12 hours fasting. After 10 minutes of medetomidine injection, 10 mg/kg ketamine (Ketamine hydrochlorid, Alfamine®, Ege Vet, İzmir) was injected intramuscularly. Anaesthesia was ceased by administration of 120 µg/kg im atipamezol (Antisedan®, Pfizer, Finland) via im route after 60 minutes of medetomidine application. Blood samples were collected from the left V. cephalica antebrachi at 0., 30. and 60. minutes and 12. and 24. hours of anaesthesia for the analyses of haematologic and biochemical parameters. Significant changes were determined in red blood cells (RBC), white blood cells (WBC) hematocrit (HCT) values and serum aspartateaminotransferase (AST), alanine aminotransferase (ALT), creatine kinase (CK) and amylase activities and blood urea nitrogen (BUN) and glucose levels. Serum CK activity at 12. and 24. hours were found to be higher than the activity measured at 0. minute. At the 24. hours, the levels of all parameters, except CK activity, returned to the baseline (0. minute) levels. The anaesthesia protocol had no effect on thrombocyte, alkaline phosphatase, gamma-glutamyltranspeptidase activities and creatinine level. In conclusion,medetomidine-ketamine-atipamezole anaesthesia protocol caused changes in some haematologic and biochemical parameters. However, these changes were within the reference range for dogs, thus this anaesthesia protocol can be used safely and easyly in small animal practice

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