Özet:

Botulinum Toxin Applications in OMU, Department of Neurology: A Retrospective Study Clostridium botulinum toxin type A blocks the cholinergic conduction at the neuromuscular conjunction by blocking acetylcholine secretion at the presynaptic region and thus produces muscle paralysis. Such effects of the toxin are in use to treat some diseases. The most frequent neurological indications are hemifacial spasm, essential blepharospasm, cervical dystonia, task-specific dystonia and post-stroke spasticity in adults.In this retrospective study, 46 patients who were tracked for botulinum toxin injections in our department between years 2003 and 2006 are. Their diagnoses, schemes of therapy, responses to botulinum toxin treatment, side effects, follow-up during injection therapies and subjective evaluations of therapy by patients are presented and discussed p e rta ining the relative literature. Clostridium botulinum type A toxine causes muscle paralysis by blocking the release of acetylcholine and colinergic transmission in the presinaptic area of the neuromuscular intersection and is used in the treatment of some diseases. For the use of toxins in neurological applications, there are indication areas such as hemispheric spasm, essential blepharospazm, cervical dystonia, tasca specific dystonia and post-inhalation development spastisity in adults. In this retrospective study, the diagnoses of 46 patients monitored in our clinic and injected botulinum toxin injections, treatment schemes, botulinum toxin treatment responses, side effects encountered in treatment and patient observations during treatment and patient subjective evaluations of treatment response were and discussed.