Özet:

Purpose: The study aims to develop the formulations of routine, microemulation (ME) and microemulation gel (MEj), which is an antioxidant effective natural compound, and to evaluate the prolonged antioxidant effectiveness. Tools and Methods: Olive/water/surface active substance in different proportions:Aid surface active substance prepared ME formulas dropless sizes, zeta potential values, viscosity and stability after waiting, centrifying and freezing processes are determined. With stable formulations determined between six different ME formulations, MEj formulations are prepared using 1% (a/h) Carbopol 938. Characterization studies, as well as the L929 mouse fibroblast cell line, have been conducted to test toxicity in cell culture, in vitro release and cell transition studies. In light of the data, the best-defined formula (F2 ME) antioxidant activity was determined by the radically polluting effect of 1,1-difenil-2-pikrilhydrazil (DPPH●) and (2,2-azino-bis3-etilbenzotiazolin-6-sulfonic acid) (ABTS●+). Results: Six different microemulsion formulations have been developed and characterized. According to the toxicity study, the formulations developed with a routine solution and routine were not toxic. The antioxidant effect of the routine amount released from the F2 code ME formula, which is defined as the best formula with the characterization, in vitro release and cell transition study data, and the DPPH● and ABTS+● radicals are proven to have an antioxidant effect. Result: As a result, this study has not a toxic effect, new, routine-loaded ME and MEj formulations have been successfully developed, prolonged antioxidant effectiveness has been proven. It is believed that the routine loaded ME formulation developed in this study creates the potential for topical application.

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