Özet:

Post-traumatic stress disorder (PTSD) is a mental illness caused by trauma following an accident involving physical injury or by mental shock such as anxiety. Although it is common in the population, the prognosis and optimal therapies for PTSD are limited. Because the molecular targets for early intervention remain unclear, a better understanding of the molecular basis of the pathogenesis of PTSD is essential to address the challenges of disease prognosis and to diagnose and treat these molecular targets. In this study, performed by processing and analyzing microarray data from two different tissues of mice exposed to stress, genes with differential expression for the two tissue types were identified, the signaling pathways in which these genes are enriched were found, the protein-protein interaction networks of these genes and the hub proteins in these networks were determined. As a result of comparing the drug repositioning studies performed separately for the two different tissue types to reverse the effects of differentially expressed genes, vorinostat, homoharringtonine, and QL-XII -47 were proposed as novel drugs for the treatment of PTSD. Vorinostat, one of these drugs, was also found to target HDAC1, HDAC2, HDAC3, HDAC6, HDAC7, and HDAC8 genes in the cell.

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