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URINARY SYSTEM INFECTIONS CAUSED BY CANDIDA KEFYR AND TREATED WITH FLUCONAZOLE (Case Report)
2009
Journal:  
Gazi Medical Journal
Author:  
Abstract:

Approximately 25% to 50% of nasocomial candida infections are seen in the medi- cal, medico-surgical, surgical, and intensive care units (ICU) and out of these 35% to 65% are the non-albicans Candida (NAC) types. C. kefyr is responsible less than 1% of the candidemias among the NAC types. Other candidas might also be pathogenic in the event of increasing use of drugs, surgical interventions, organ transplantations, and AIDS, which damage the immunity system of individuals. It has been observed that the most sticky type is C. albicans and that this characteristic is not found in C. kefyr. This difference indicates a relationship between adherence and pathogenity. Although amphotericine B treatment has been suggested for patients who have C. kefyr multiplication in their urine, in our patient we applied fluconazole and the pati- ent responded. Therefore, in the treatment of patients who are elderly and who have a history of surgical interventions and diabetes mellitus, instead of amphotericine B, which has many nephrotoxic and systemic side effects, we selected fluconazole as an anti-fungal as a drug in our treatement and got a response from our patient and we wished to present our case. Anahtar Kelimeler: Candida Kefyr, Flukonozal, Yoğun Bakım Ünitesi   FLUKONAZOLLE TEDAVİ EDİLEN CANDİDA KEFYR’E BAĞLI BİR ÜRİNER SİSTEM EN- FEKSİYONU (Olgu Sunumu) ABSTRACT Nazokomiyal Candida enfeksiyonlarının yaklasık % 25-50’si medikal, medikal- cerrahi, cerrahi Yoğun bakım ünitelerinde (YBÜ) görülüp, bunların da % 35-65’inden Non-albicans Candida (NAC) türleri sorumludur. C. kefyr NAC türleri içerisindeki kandidemilerin % 1’inden daha azın- dan sorumludur. Artan ilaç kullanımı, cerrahi girisimler, organ nakilleri ve AIDS gibi bireyin bağısık- lığını bozan durumlarda, diğer candidalar da patojen olabilir. En fazla yapısma yete- neği bulunan türün C. albicans olduğu, ancak bu özelliğin C. kefyr’de bulunmadığı gözlemlenmistir. Bu farklılık adherens ile patojenliğin iliskisine isaret etmektedir. Đdrarda C. kefyr üreyen hastalarda genelde tedavide amfoterisin B önerilmesine rağmen, bizim hastamızda uyguladığımız gibi Flukonazol verilerek tedaviye yanıt alınması nedeniyle bu sekilde ileri yasta olan, cerrahi girisim ve Diabetes Mellitus öyküsü olan hastalarda tedavide amfoterisin B gibi nefrotoksik ve sistemik yan etki- leri çok olan bir ilaç yerine antifungal olarak Flukonazol tedavisine cevap veren bir olgumuzu sunmayı amaçladık. Key words: Candida Kefyr, Fluconazole, İntensive Care Unit

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Gazi Medical Journal

Field :   Sağlık Bilimleri

Journal Type :   Uluslararası

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Gazi Medical Journal