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Hipotiroidizm plevral, perikardiyal efüzyon veya asit yapabilir. Miksödemin başlıca bulguları sıvı retansiyonu, hiponatremi ve hidrofilik mukopolisakkaritlerin intersisyel birikimidir. Hipotiroidizm glomerüler filtrasyon oranının azalması ile beraberdir. Azalmış glomerüler filtrasyon oranı ise idrarın dilüsyonundan sorumlu kısımlara gelen su miktarını azaltarak serbest su atılımını azaltır. Hipotiroidizme bağlı seröz efüzyonların genellikle protein düzeyleri yüksek olduğu için altta yatan mekanizma muhtemelen vasküler permeabilite artışıdır. Miksödem olgularında efüzyon oluşumunun gerçek mekanizması bilinmemektedir. Vasküler Endotelyal Growth Faktör kapiller permeabiliteyi artırmaktadır ve bu faktörün düzeyleri hipotiroidizm olgularında yüksek olup tiroid hormon replasman tedavisiyle normale dönmektedir
Hypothyroidism can be pleural, pericardal fusion or acid. The main findings of mixedemia are the intersicular accumulation of fluid retention, hyponatromy and hydrophylic mukopolysaccharides. Hypothyroidism is associated with a decrease in the glomerular filtration rate. The reduced glomerular filtration rate reduces the amount of water coming to the parts responsible for the dilusion of the urine by reducing the free flow of water. The underlying mechanism is likely to be an increase in vascular permeability, since hypotiroidism-related serum physions are usually high in protein levels. The actual mechanism of the formation of the fusion is unknown. Vascular Endotelyal Growth Factor increases capillary permeability and the levels of this factor are high in hypothyroidism and thyroid hormone replacement treatment returns to normal.
Hypothyroidism can cause pleural or pericardial effusion, and ascites. The main manifestations of myxedema include retention of fluid, hyponatremia, and interstitial deposition of hydrophilic mucopolysaccharides. Hypothyroidism is associated with reduced glomerular filtration rate. Reduced glomerular filtration rate can directly decrease free water excretion by diminishing water delivery to the diluting segments. As the serous effusions due to hypothyroidism have generally high levels of protein, the underlying mechanism is probably increased vascular permeability. The precise mechanism of effusion formation in patients with myxedema is unclear. Vascular Endothelial Growth Factor also increases capillary permeability. The levels of this factor are elevated in patients with hypothyroidism and return to normal with thyroid replacement therapy
Alan : Sağlık Bilimleri
Dergi Türü : Uluslararası
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