Abstract:

The main objective of the study was to evaluate the relationship between serum endocant levels and clinical conditions in Coronavirus Disease-2019 (COVID-19) patients. Secondly, we aimed to reveal the relationship between serum endocant levels and other inflammatory parameters in terms of clinical results. Method: The study included a total of 80 COVID-19 patients who were over the age of 18, with a positive polymerase chain reaction test, 44 stable, 36 in critical conditions, the first application complaint was not a heart attack or ischemic stroke. Patients’ characteristics and clinical results, hematological and biochemical parameters, endocan levels, computational tomographs, treatment approaches, vital findings and COVID-19 symptoms were evaluated. Results: The average age of critical patients was significantly higher than stable patients (71,00±13,27 and 53,36±17,80; p<0,001). In critical patients, the blood and serum parameters (C-reactive protein, ferritin, procalcitonin, lactate, neutrophil-lenfocytes, D-dimer, troponin T, urine, creatine, white blood cells and international normalized rates) were significantly higher (p<0,05). Serum endocant levels were significantly increased in critical patients (518,9±513.31 ng/mL; p<0,001). Endocane, age, laktate, and troponin T were found to be significantly effective in distinguishing critical patients from stable patients. For critical patients, 244.9 ng/mL endocan levels were observed with 88.9 % sensitivity and 63.6 % specificity. Result: Serum endocan levels are a useful biological indicator for predicting the clinical condition in the application and can predict the prognosis and results of COVID-19 patients.

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