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17
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1
In this study, novel mefenamic acid derivatives were prepared as binary and tertiary molecule drug delivery system binding by hydrazide as a bridge. The compound AY1 was used as a starting material for the production of tri-molecule pharmaceutical compounds by reacting it firstly with hydrazide to give AY1H,which reacted with four different carboxylic drugs (Naproxen, Ibuprofen, Captopril, Methyldopa) to produce the new compounds (AY20-AY23) respectively. All the prepared compounds were characterizedby FT-IR, 1HNMR and 13CNMR. The physical properties of the synthesized compounds were also determined and their solubility in different solvents. The biological activity as antibacterial effect against different bacteriawas studied and showed bactericidal effect.
Alan : Fen Bilimleri ve Matematik; Sağlık Bilimleri
Dergi Türü : Uluslararası
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