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Amaç: Bu çalışmada rekürren alt ekstremite selüliti nedeniyle takip edilen hastalarda risk faktörlerinin değerlendirilmesi ve laboratuvar bulguları ile klinik bulguların tedavi yanıtı üzerine etkisinin değerlendirilmesi amaçlanmıştır. Gereç ve Yöntem: Eylül 2011 ve Ekim 2015 tarihleri arasında Sağlık Bakanlığı İstanbul Medeniyet Üniversitesi Göztepe Eğitim ve Araştırma Hastanesi Enfeksiyon Hastalıkları kliniğinde yatırılarak takip edilen alt ekstremite selüliti tanısı almış 18 ile 91 yaş arası tüm hastalar çalışmaya alınmıştır. Hasta dosyaları ve epikrizleri taranarak hasta bilgilerine ulaşılmıştır. Hastaların demografik özellikleri, eşlik eden hastalıkları, predispozan faktörleri, en son geçirdiği selülit atağı ve özellikleri, başvuru semptomları, fizik muayene bulguları, laboratuvar değerleri, verilen antibiyotik tedavisi, 72.saatteki kontrol laboratuvar değerleri incelenmiştir. Bulgular: Bu çalışmaya 93 hasta dâhil edilmiştir ve 40’ında (%43) rekürrens saptanmıştır. Rekürrens öyküsü olan ve olmayan hastalar karşılaştırılmış hastalarda risk faktörü olarak tinea pedisin (p=0.038) olması ve eşlik eden koroner arter hastalığının (p=0,015) olması rekürrens yönünden istatistiksel olarak anlamlı saptanmıştır. Rekürrens öyküsü olan ve olmayan hastaların başvuru lökosit sayısı (BK), CRP değerleri ile 72. saatteki laboratuvar değerleri karşılaştırıldığında istatistiksel olarak anlamlı fark saptanmamıştır. Antibiyoterapi başlanan hastaların 28’inde tedavi yanıtsızlığı düşünülerek 48-72 saat sonra antibiyoterapi değişimi yapılmıştır. Antibiyoterapi değişimi ile laboratuvar bulguları karşılaştırıldığında yatış BK (p=0,016), yatış CRP (p=0,024), 72. saatteki BK (p=0,01) ve 72. saatteki CRP (p=0,001) değerlerinde istatistiksel anlamlılık tespit edilmiştir. Aynı zamanda başvuru esnasında alt ekstremitede şiddetli ağrı yakınması olan hastalar ile antibiyotik tedavi değişim gerekliliği arasında ilişki olduğu gözlenmiştir (p=0,019). Sonuç: Rekürren alt ekstremite selüliti öyküsü olan hastalarda eşlik eden tinea pedis ve koroner arter hastalığının olması yeni bir selülit atağı için risk faktörü olarak değerlendirilebilir. Başvuru esnasında yüksek BK ve CRP değeri olan ve 72. saatteki kontrol değerlerinin halen yüksek seyrettiği hastalarda tedavi yanıtsızlık riskinin daha fazla olacağı düşünülebilir. Başvuru esnasında şiddetli ağrı öyküsü olan hastalarda olmayanlara göre tedavi değişikliği ihtiyacı olma ihtimali daha fazladır.
Purpose: This study aims to evaluate risk factors in patients traced due to recurrenal lower end cellulite and to evaluate the effect of laboratory findings and clinical findings on the treatment response. Tools and methods: between September 2011 and October 2015 the Ministry of Health of Istanbul Civilization University Göztepe Education and Research Hospital Infectious Diseases Clinic was followed by all patients aged 18 to 91 who were diagnosed with lower end cellulite. Patient records and epicrises have been scaned to the patient’s information. The demographic characteristics of patients, accompanying diseases, predisposing factors,the last cellulite attack and characteristics, application symptoms, physical examination findings, laboratory values, antibiotic treatment given, laboratory values checked at 72. Results: 93 patients were included in this study and 40 (43%) were recurrent. Patients with a history of recurrence and non-recurrence have been compared; the risk factor in patients is tinea pedisin (p=0.038) and the accompanying coronary artery disease (p=0.015) has been statistically meaningful in terms of recurrence. The applicable number of leukocytes (BK) of patients with and without recurrence history, with CRP values 72. When compared the laboratory values in the hour, there was no statistically meaningful difference. In 28 patients who started antibiotics, an antibiotic replacement was taken after 48-72 hours, considering therapeutic insufficiency. Comparing antibiotic therapy and laboratory findings, statistical significance was identified in the values of inflation BK (p=0,016), inflation CRP (p=0,024), 72 hour inflation BK (p=0,01) and 72 hour inflation CRP (p=0,001). It was also observed a relationship between patients with severe pain in the lower limb during the application and the need for antibiotic treatment exchange (p=0,019). The result: having tinea pedis and coronary artery disease accompanied in patients with recurrent sub-extreme cellulite history can be considered a risk factor for a new cellulite attack. Patients with high BK and CRP values at the time of application and whose control values at 72 hours are still high will have a higher risk of treatment failure. Patients with no severe pain history during application are more likely to need a change in treatment than those with no severe pain history during application.
Aim: To determine the risk factors of patients followed with recurrent lower extremity cellulitis and to find out the effect of clinical and laboratory findings on treatment response. Material and Method: This retrospective study was conducted between September 2011 and June 2016 at Infectious Disease clinic of Istanbul Medeniyet University Education and Research Hospital and all hospitalized patients diagnosed as lower extremity cellulitis, aged between 18-91, were involved. Data of all patients was determined by searching patients files and epicrisis. Demographic features, accompanying disease, predisposing factors, last cellulitis attack and its features, patients symptoms at hospitalization day, physical examination findings, laboratory values, given antibiotics and control laboratory values at 72 h were investigated. Results: Totally 93 patients with a diagnosis of lower extremity cellulitis, 40 (43%) of whom had recurrent cellulitis were included in the study, Patients with a history of recurrent cellulitis compared with patients with first attack. Patients having tinea pedis (p=0.038) and diagnosed as coronary artery disease (0.015) were found statistically significant for recurrent cellulitis. Patients white blood cell (WBC), c-reactive protein (CRP) value at hospitalization day and control laboratory values at 72 h were compared and no statistically significant data obtained. Treatment change has done after 48-72 hours on 28 of patients whom receiving antibiotherapy with the idea of treatment failure. Between patients considering unresponsiveness to antibiotic therapy and undergone treatment change, statistically significant differences were detected for WBC (p=0.016) and CRP (0.024) value at the day of hospitalization, control WBC (0.01) and CRP (0.001) value at 72 h. Similarly, statistically significant results for the patients had severe pain in lower extremity at the day of hospitalization were obtained (p=0.019). Conclusion: Patients having tinea pedis and accompanying coronary artery disease are more probable to new cellulitis attack whose had a history of recurrent lower extremity cellulitis. The risk would be more through nonresponder patients whom WBC and CRP value were high at hospitalization day and the continuation of high WBC and CRP values at 72 h were detected. In patients undergone treatment change, statistically significant differences were detected between patients have severe pain in lower extremity at the day of hospitalization and patients not.
Alan : Sağlık Bilimleri
Dergi Türü : Ulusal
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