Abstract:

Background: Malnutrition causes nutritional, metabolism, and biochemical disorders and finally leads to mortality. Several studies have highlighted that serum liver enzymes are increased and serum total proteinis decreased in patients with malnutrition. Objectives: This study aimed to evaluate the relationship between malnutrition and liver biochemical marker (serum total protein , albumin, globulin, bilirubin, ALP, AST and ALT) in MP, India. Materials and Methods: Present study comprises 120 participants of matched gender and age from the same population, 60 participants served as healthy controls, and 60 participants as cases of Malnutrition, with an age group ranging from 6 months- 5 years. serum (serum total protein , albumin, globulin, bilirubin, ALP, AST and ALT)was estimated by Biosystems A-25 Fully Automated analyser was used for measurement. Result: The liver biomedical marker were significantly (p>0.05) raised in clinically diagnosed hypothyroid patients as compared to age and gender match healthy control subjects. Conclusions: The findings indicated that there was Significantly low levels of total protein, albumin and globulin are present in our study population, No significant difference in the serum bilirubin values in malnourished children as compared to controls and there was no significant alteration in enzyme markers in the two groups. However, AST and ALT levels increased, and ALP levels decreased compared with the control. Different degrees of malnutrition, including mild, moderate, and severe, can probably change the levels of hepatic enzymes in under-nourished children. Alteration of these liver enzymes could be due to the metabolic modification, which can be the result of protein deficiency.

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