Abstract:

Introduction: In the present study, it was aimed to evaluate the effects of the maternaland infantile factors and factors associated with the care of the infants in the development of necrotizing enterocolitis NEC . Materials and Method: Infants with ≤32 weeks of gestational age and ≤1500 gramsof birth weight were included in the study. Maternal demographic characteristicsand pregnancy history, antenatal and postnatal follow-up problems, antenatalsteroid treatment, modes of delivery NVY, C/S , and the babies’ birth history wererecorded. The duration of ventilation treatment and the number of transfusionsapplied before the diagnosis of NEC in premature infants were recorded. Patientswith stage II and stage III NEC were included in the study.Results: Sixty one of 532 patients 11,4% were diagnosed as NEC and allocated in thestudy group. Sixty patients were enrolled as the control group. There were no differencesbetween both groups with respect to demographic characteristics, APGAR score, need for resuscitation and antenatalsteroid treatment. The duration of ventilation treatment p=0.037 and the frequency of red blood cell transfusion p=0.032 were considered to be higher in the NEC group. Antenatal steroid administration was higher in patients with stage 2 NEC p=0.011 , but the duration of ventilation treatment was higher in those with stage 3 p=0.020 . The mortality rate was 31.1%in the patients with NEC. It was observed that 83% of patients who died had stage 3 NEC and a lower birth weight and gestational age. Respiratory distress syndrome RDS p=0.02 , togetherness of RDS and patent ductus arteriosus PDA werehigher in the NEC group p=0.03 , and more intracranial hemorrhage ICH was detected at stage 3 NEC p=0.034 . RDS, PDAand İCH were frequently determined together in patients with stage 3 NEC p=0.006 . Chronic hypertension p=0.003 ,eclampsia p=0.034 , and infection p=0.011 were found to be more frequent in the mother of the patients with stage 3 NEC. Conclusion: In the present study, antenatal, natal and postnatal factors were shown to play an important role in the development of NEC, and if proposed measures to be taken, these factors may reduce the incidence of the disease. Journal

Keywords: