Abstract:

The occurence of adverse reactions to allergen spesific immunotherapy is rare. Most of them appear within 30 minutes after injection. The reactions occurring after 30 minutes are called as late side effects. Usually treatment dropout is not required. In this paper, we present a case that required discontinuation of the treatment because of developing of a late systemic side effect that had never been reported before. Subcutaneous pre-seasonal immunotherapy was planned to a 23 year-old man with seasonal allergic rhinitis. The patient received subcutaneous pre-seasonal immunotherapy for 2 times with 1 week interval. Ten hours after first administration, he had complaints of fever, discomfort, myalgia and tiredness. Planned immunotherapy regimen was continued and same complaints were repeated 12 hours after second injection. Fever could not be controlled with medication and went on for 3 days. Complaints of generalized myalgia, discomfort, artralgia and tiredness accompanied with the fever. These clinical findings were suggested as systemic adverse reactions of immunotherapy and the treatment is discontinued. Patients should be informed about the side effects that could appear in late period and in case of side effect occuring, the treatment protocol should be overviewed again.

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