Özet:

INTRODUCTION: In this study, we aimed to evaluate maternal and fetal outcomes in pregnant women diagnosed with intrahepatic cholestasis of pregnancy (ICP) in our clinic. METHODS: In this retrospective study, we included a total of 53 patients with ICP who were admitted to Bursa Higher Education Training and Research Hospital, Obstetrics and Gynecology outpatient clinics between September 2017 and September 2018. The diagnosis of ICP was made based on elevated liver enzymes and even acids (≥10 μmol/L) and pruritis. Delivery outcomes and demographic characteristics of the patients were obtained from the hospital records. Results: The average age of the patients was 30.5±5.7 years and the average gestational age was 32.3±2.8 weeks. The average even acid level was 26.42±19.1 μmol/L. of the patients, 26. 4% had gestational diabetes mellitus and 15.1% had preeclampsia. A total of 37.7% of the patients had premature delivery. Of all neonates, 32.7% required neonatal intensive care unit stay, while 32.7% had transient tachypnea of the newborn and 33.3% had respiratory distress syndrome. No perinatal mortality was observed. DISCUSION AND CONCLUSION: Our study results suggest that close follow-up and identification of patients with severe cholestasis symptoms are the mainstays of the follow-up of ICP and early treatment to decrease perinatal mortality and morbidity.

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