Abstract:

Purpose: Long-term transfusion therapy, extravasal hemolysis and increased intestinal absorption of iron in patients with talasemia major leads to excess iron burden. As a result, hemosiderosis develops in many organs, especially in the heart. Tools and Methods: In our hospital, the average age group of 13±7 years of age, all of our 85 patients who received shelator treatment were evaluated cardiocardiography and MR T2* and cardiocystolic and diastolic functions. Results: There was no significant difference in heart functions (systolic and diastolic) when grouped according to the values of ferritin (under and above 2,500 of ferritin) and the values of heart MR T2* (20 of six and above). In comparison with the control group of talasemili patients, a reduction in the tissue Doppler and the left ventricular diastolic functions and a significant increase in the left ventricular muscle mass (LV mass) index have been observed. The result: In our study, the cardiovascular geometry was deteriorated in talasemian patients and the right and left diastolic functions were reduced in the tissue Doppler study.

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