Özet:

Objective: Thyroid dysfunction is known to increase the risk of cardiovascular disease (CVD) in patients with Hashimoto's thyroiditis (HT). However, there is insufficient data regarding CVD risk in euthyroid HT patients who have not yet developed thyroid dysfunction. In our study, we investigated whether Asymmetric Dimethylarginine (ADMA), Symmetric Dimethyl Arginine (SDMA), N-Monomethyl-L-Arginine (L-NMMA), Arginine and Citrulline levels can be used as early indicators of this risk. Materials and Methods: 63 pubertal female patients without thyroid dysfunction and 68 healthy controls, who were diagnosed with HT based on thyroid antibody positivity and ultrasonographic findings, were included in our study. Blood pressure levels, thyroid function test data, thyroid antibody levels, inflammatory parameters and ADMA, SDMA, L-NMMA, Arginine and Citrulline levels were compared between the groups, and the relationships of ADMA, SDMA, L-NMMA, Arginine and Citrulline levels with other CVD markers were determined. Results: While TSH, anti-TPO, anti-Tg and ADMA values were found to be high in the patient group; Citrulline, arginine and arginine/ADMA values were found to be low. While a significant positive correlation was observed between ADMA and SDMA, L-NMMA, fT3, total cholesterol, LDL, triglyceride, waist circumference/hip circumference and BMI SSS values in the patient group, a significant negative correlation was detected with arginine/ADMA values. Conclusion In our study, patients with euthyroid Hashimoto's thyroiditis; In the early period, an increase in ADMA levels was detected. ADMA can be used as a CVD risk indicator in patients with euthyroid hypertension due to its relationships with anthropometric measurements, metabolic parameters, SDMA and L-NMMA.

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