Özet:

Modern intensive technologies for handling and growing highly productive animals are accompanied by significant changes in their homeostasis causing stress and adversely affecting their health and the quality of the products obtained from them. Depending on the cause, stress is classified as social (technological), environmental, dietary, and immunological. Various types of stress adversely affect the body and contribute to endocrine, energy balance, and carbohydrate-lipid metabolism disturbances, which adversely affects the animal resistance to diseases, productivity and reproductive characteristics. Stress leads to metabolic disorders and changes in the ratio of muscle and fatty tissues. Every year, the manifestations of antemortem and postmortem pathological changes in the microstructure of animal muscle tissue are increasingly noted. Moreover, the affected structures of muscle fibers are characterized by hyper contraction, disruption of cell membranes, and formation of extracellular protein substance represented by denatured forms of proteins reducing the nutritional value and consumer characteristics of the final product. The use of antioxidants in pig diets, including natural ones, helps to reduce the impact of environmental stress factors on animals and increase their adaptive capacity. This review focuses on the ways to reduce stress and the effect of flavonoids, including quercetin, whose properties have been extensively studied in recent years, in order to increase the resistance of highly productive animals to various stress factors.  Keywords: Pigs; stress; nutrition; flavonoids; quercetins References: Averós, X., Herranz, A., Sánchez, R., & Gosálvez, L. F. (2009). Effect of the duration of commercial journeys between rearing farms and growing–finishing farms on the physiological stress response of weaned piglets. Livestock Science, 122(2-3), 339-344. doi: https://doi.org/10.1016/j.livsci.2008.09.019. Baumgard, L. H., & Rhoads Jr, R. P. (2013). Effects of heat stress on postabsorptive metabolism and energetics. Annu. Rev. Anim. Biosci., 1(1), 311-337. doi: https://doi.org/10.1146/annurev-animal-031412-103644. BloEMhoF, S., Van der Waaij, E. H., Merks, J. W. M., & Knol, E. F. (2008). Sow line differences in heat stress tolerance expressed in reproductive performance traits. Journal of Animal Science, 86(12), 3330-3337. doi: https://doi.org/10.2527/jas.2008-0862. Boddicker, R. L., Seibert, J. T., Johnson, J. S., Pearce, S. C., Selsby, J. T., Gabler, N. K., Lucy, M. C., Safranski, T. J., Rhoads, R. P., Baumgard, L. H. & Ross, J. W. (2014). Gestational heat stress alters postnatal offspring body composition indices and metabolic parameters in pigs. PLoS ONE, 9(11), e110859. doi: https://doi.org/10.1371/journal.pone.0110859. Cadenas, E. & Packer, L. (2002). Handbook of antioxidants: second edition, revised and expanded. New York: Marcel Dekker. Campbell, J. M., Crenshaw, J. D., & Polo, J. (2013). The biological stress of early weaned piglets. Journal of animal science and biotechnology, 4(1), 19. doi: https://doi.org/10.1186/2049-1891-4-19. Carpenter, R., O’grady, M. N., O’callaghan, Y. C., O’brien, N. M., & Kerry, J. P. (2007). Evaluation of the antioxidant potential of grape seed and bearberry extracts in raw and cooked pork. Meat science, 76(4), 604-610. doi: https://doi.org/10.1016/j.meatsci.2007.01.021. Costa, L. G., Garrick, J. M., Roquè, P. J., & Pellacani, C. (2016). Mechanisms of neuroprotection by quercetin: counteracting oxidative stress and more. Oxidative medicine and cellular longevity, Article ID 298679610, 10 p. http://dx.doi.org/10.1155/2016/2986796. Coutellier, L., Arnould, C., Boissy, A., Orgeur, P., Prunier, A., Veissier, I., & Meunier-Salaün, M. C. (2007). Pig's responses to repeated social regrouping and relocation during the growing-finishing period. Applied Animal Behaviour Science, 105(1-3), 102-114. doi: https://doi.org/10.1016/j.applanim.2006.05.007. de Oliveira, A. C. D. F., Vanelli, K., Sotomaior, C. S., Weber, S. H., & Costa, L. B. (2019). Impacts on performance of growing-finishing pigs under heat stress conditions: a meta-analysis. Veterinary research communications, 43(1), 37-43. doi: https://doi.org/10.1007/s11259-018-9741-1. Danilevskaya, N. V., & Tukhfatova, N. F. (2012). Ispolzovaniye metoda selektivnoy dekontaminatsii pri otyeme porosyat. Agrarnyy vestnik Urala, 5, 36-39 (in Russian). Danilkina, O. P. (2015). Fiziologiya stressa: metodicheskiye ukazaniya. Krasnoyarsk (in Russian). Dröge, W. (2002). Free radicals in the physiological control of cell function. Physiol Rev, 82(1), 47-95. doi: https://doi.org/10.1152/physrev.00018.2001. Einarsson, S., Brandt, Y., Lundeheim, N., & Madej, A. (2008). Stress and its influence on reproduction in pigs: a review. Acta Veterinaria Scandinavica, 50(1), 48. doi: https://doi.org/10.1186/1751-0147-50-48. Febbraio, M. A. (2001). Alterations in energy metabolism during exercise and heat stress. Sports medicine, 31(1), 47-59. doi: https://doi.org/10.2165/00007256-200131010-00004. Fomichev, Yu. P., Nikanova, L. A., & Netecha, Z. A. (2011). Bioprotektornoye deystviye digidrokvertsetina i arabinogalaktana v oslablenii ekstremalnykh effektov sredy na organizm zhivotnykh. Vetkorm, 4, 30-31 (in Russian). Fomichev, Yu. P., Nikanova, L. A., Dorozhkin, V. I., Torshkov, A. A., Romanenko, A. A., Es'kov, E. K., Semenova, A. A., Gonockij, V. A., Dunaev, A. V., YAroshevich, G. S., Lashin, S. A., & Stol'naya, N. I. (2017). Digidrokvercetin i arabinogalaktan – prirodnye bioregulyatory v zhiznedeyatel'nosti cheloveka i zhivotnyh, primenenie v sel'skom hozyajstve i pishchevoj promyshlennosti. Moskva. Nauchnaya biblioteka (in Russian). Franki?, T., Levart, A., & Salobir, J. (2010). The effect of vitamin E and plant extract mixture composed of carvacrol, cinnamaldehyde and capsaicin on oxidative stress induced by high PUFA load in young pigs. Animal, 4(4), 572-578. doi: https://doi.org/10.1017/S1751731109991339. Garcia, A., Sutherland, M., Pirner, G., Picinin, G., May, M., Backus, B., & McGlone, J. (2016). Impact of providing feed and/or water on performance, physiology, and behavior of weaned pigs during a 32-h transport. Animals, 6(5), 31. doi: https://doi.org/10.3390/ani6050031. Garcia, A., Pirner, G., Picinin, G., May, M., Guay, K., Backus, B., Sutherl, M. & McGlone, J. (2015). Effect of provision of feed and water during transport on the welfare of weaned pigs. Animals, 5(2), 407-425. doi: https://doi.org/10.3390/ani5020363. Gupta, S., & Abu-Ghannam, N. (2011). Recent developments in the application of seaweeds or seaweed extracts as a means for enhancing the safety and quality attributes of foods. Innovative Food Science & Emerging Technologies, 12(4), 600-609. doi: https://doi.org/10.1016/j.ifset.2011.07.004. Gusev, V. A., & Panchenko, L. F. (1982). Superoksidnyy radikal i superoksiddismutaza v svobodnoradikalnoy teorii stareniya. Voprosy meditsinskoy khimii, 28(4), 8-25 (in Russian). Habanova, M., & Haban, M. (2008). Evaluation of antiradical activity of chosen plant resources. Acta Fytotechnica et Zootechnica, 1, 21-24. Hao, Y., Feng, Y., Yang, P., Feng, J., Lin, H., & Gu, X. (2014). Nutritional and physiological responses of finishing pigs exposed to a permanent heat exposure during three weeks. Archives of animal nutrition, 68(4), 296-308. doi: https://doi.org/10.1080/1745039X.2014.931522. Holinger, M., Früh, B., Stoll, P., Graage, R., Wirth, S., Bruckmaier, R., Prunier, A., Kreuzer, M., & Hillmann, E. (2018). Chronic intermittent stress exposure and access to grass silage interact differently in their effect on behavior, gastric health and stress physiology of entire or castrated male growing-finishing pigs. Physiology & Behavior, 195, 58-68. doi: https://doi.org/10.1016/j.physbeh.2018.07.019. Janz, J. A. M., Morel, P. C. H., Wilkinson, B. H. P., & Purchas, R. W. (2007). Preliminary investigation of the effects of low-level dietary inclusion of fragrant essential oils and oleoresins on pig performance and pork quality. Meat Science, 75(2), 350-355. doi: https://doi.org/10.1016/j.meatsci.2006.06.027. Johnson, J. S., & Baumgard, L.H. (2019). Physiology symposium: postnatal consequences of in utero heat stress in pigs. Journal of Animal Science, 97(2), 962-971. doi: https://doi.org/10.1093/jas/sky472. Johnson, J. S., Abuajamieh, M., Sanz Fernandez, M. V., Seibert, J. T., Stoakes, S. K., Nteeba, J., & Baumgard, L. H. (2015). Thermal stress alters postabsorptive metabolism during pre- and postnatal development. Book Chapter: Thermal Stress Alters Postabsorptive Metabolism During Pre- and Postnatal Development, 61-80. doi: https://doi.org/10.1007/978-81-322-2265-1_5. Johnson, J. S., Sanz Fernandez, M. V., Gutierrez, N. A., Patience, J. F., Ross, J. W., Gabler, N. K., & Baumgard, L. H. (2015). Effects of in utero heat stress on postnatal body composition in pigs: I. Growing phase. Journal of Animal Science, 93(1), 71-81. doi: https://doi.org/10.2527/jas.2014-8354. Kamyshnikov, V. S. (2003). Sistema perekisnoye okisleniye lipidov - antioksidantnaya zashchita organizma. Kliniko-biokhimicheskaya laboratornaya diagnostic. Sainct Petersburg (in Russian). Klimenko, A. S., & Trukhin, D. A. (2012). Teplovoy stress u sviney i ego profilaktika. Svinovodstvo, 2, 31-32 (in Russian). Knyazev, V. V., Rogovskii, V. S., Sveshnikova, E. D., Semeikin, A. V., Matyushin, A. I., Fedotcheva, T. A., Shimanovskii, N. L., Pozdeev, A. O., Koroteev, A. M., & Koroteev, M. P. (2018). Synthesis and Antioxidant and Cytotoxic Activity of New Dihydroquercetin Derivatives. Pharmaceutical Chemistry Journal, 52(3), 205-208. Doi: https://doi.org/10.1007/s11094-018-1791-8  Lahucky, R., Nuernberg, K., Kovac, L., Bucko, O., & Nuernberg, G. (2010). Assessment of the antioxidant potential of selected plant extracts - in vitro and in vivo experiments on pork. Meat Science, 85(4), 779–784. doi: https://doi.org/10.1016/j.meatsci.2010.04.004 Costa, L. G., Garrick, J. M., Roquè, P. J., & Pellacani, C. (2016). Mechanisms of neuroprotection by quercetin: counteracting oxidative stress and more. Oxidative medicine and cellular longevity, Article ID 2986796. Doi: https://doi.org/10.1155/2016/2986796. MacIver, N. J., Jacobs, S. R., Wieman, H. L., Wofford, J. A., Coloff, J. L., & Rathmell, J. C. (2008). Glucose metabolism in lymphocytes is a regulated process with significant effects on immune cell function and survival. Journal of leukocyte biology, 84(4), 949-957. doi: https://doi.org/10.1189/jlb.0108024. Mariassyova, M. (2006). Antioxidant activity of some herbal extracts in rapeseed and sunflower oils. Journal of Food and Nutrition Research, 45(3), 104-109. Martínez-Miró, S., Tecles, F., Ramón, M., Escribano, D., Hernández, F., Madrid, J., Orengo, J., Martinez-Subiela, S., Manteca, X. & Cerón, J. J. (2016). Causes, consequences and biomarkers of stress in swine: an update. BMC Veterinary Research, 12, 171. doi: https://doi.org/10.1186/s12917-016-0791-8. McLamb, B. L., Gibson, A. J., Overman, E. L., Stahl, C., & Moeser, A. J. (2013). Early weaning stress in pigs impairs innate mucosal immune responses to enterotoxigenic E. coli challenge and exacerbates intestinal injury and clinical disease. PloS one, 8(4), e59838. doi: https://doi.org/10.1371/journal.pone.0059838. Menshikova, E .B. (2006). Okislitelnyy stress. Prooksidanty i antioksidanty. Moskva: Firma “Slovo” (in Russian). Minotti, G., & Aust, S. D. (1989). The role of iron in oxygen radical mediated lipid peroxidation. Chemico-biological interactions, 71(1), 1-19. Moroney, N. C., O'Grady, M. N., O'Doherty, J. V., & Kerry, J. P. (2012). Addition of seaweed (Laminaria digitata) extracts containing laminarin and fucoidan to porcine diets: Influence on the quality and shelf-life of fresh pork. Meat science, 92(4), 423-429. doi: https://doi.org/10.1016/j.meatsci.2012.05.005. Nikanova, L. A., Fomichev, Yu. P., & Narizhnyy, A. G. (2017). Primeneniye digidrokvertsetina antioksidanta i arabinogalaktana prebiotika v svinovodstve: Rukovodstvo. Dubrovitsy: VIZh im. L.K. Ernsta (in Russian). Nikanova, L. A., & Fomichev, Yu. P. (2012). Rol kormovykh dobavok v oslablenii ekologi4545cheskogo temperaturnogo stressa u sviney. Rossiyskiy zhurnal. Problemy veterinarnoy sanitaria, gigiyeny i ekologii, 1(7), 62-65 (in Russian). Ott, O., Soler, L., Moons, C. P. H., Kashiha, M. A., Bahr, C., Vandermeulen, J., Janssens, S., Gutiérrez, A. M., Escribano, D, Cerón, J. J., Berckmans, D., & Tuyttens, F. A. M. (2014). Different stressors elicit different responses in the salivary biomarkers cortisol, haptoglobin, and chromogranin A in pigs. Res Vet Sci, 97, 124–128. doi: https://doi.org/10.1016/j.rvsc.2014.06.002. Pearce, S. C., Gabler, N. K., Ross, J. W., Escobar, J., Patience, J. F., Rhoads, R. P., & Baumgard, L. H. (2013). The effects of heat stress and plane of nutrition on metabolism in growing pigs. Journal of animal science, 91(5), 2108-2118. doi: https://doi.org/10.2527/jas.2012-5738. Pereira, T. L., Corassa, A., Komiyama, C. M., Araújo, C. V., & Kataoka, A. (2015). The effect of transport density and gender on stress indicators and carcass and meat quality in pigs. Spanish Journal of Agricultural Research, 13(3), 0606. doi: https://doi.org/10.5424/sjar/2015133-6638. Plyashchenko, S. I. & Sidorov, V. T. (1983). Preduprezhdeniye stressov u selskokhozyaystvennykh zhivotnykh. Minsk. Uradzhay (in Russian). Pshennikova, M. G. (2000). Fenomen stressa. Emocional'nyj stress i ego rol' v patologii (prodolzhenie). Patologicheskaya fiziologiya i eksperimental'naya terapiya, 4, 21-31(in Russian). Rapiyev, R. A., & Mannapova, R. T. (2013). Biokhimicheskiy status organizma zhivotnykh kak kompensatorno-regulyatornaya reaktsiya na fone deystviya stressa. Fundamentalnyye issledovaniya, 10-12, 2663-2666 (in Russian). Remience, V., Wavreille, J., Canart, B., Meunier-Salau, M. C., Prunier, A., Bartiaux-Thill, N., Nicks, B., & Vandenheede, M. (2008). Effects of space allowance on the welfare of dry sows kept in dynamic groups and fed with an electronic sow feeder. Appl Anim Behav Sci, 112, 284-296. doi: https://doi.org/10.1016/j.applanim.2007.07.006. Rogovskii, V. S., Matyushin, A. I., Shimanovskii, N. L., Semeikin, A. V., Kukhareva, T. S., Koroteev, A. M., Koroteev, M. P., & Nifant'ev, E. E. (2010). Antiproliferative and antioxidant activity of new dihydroquercetin derivatives. Eksperimental'naya i Klinicheskaya Farmakologiya, 73(9), 39-42 (in Russian). Ross, J. W., Hale, B. J., Gabler, N. K., Rhoads, R. P., Keating, A. F., & Baumgard, L. H. (2015). Physiological consequences of heat stress in pigs. Animal Production Science, 55(12), 1381-1390. doi: https://doi.org/10.1071/AN15267. Ross, J. W., Hale, B. J., Seibert, J. T., Romoser, M. R., Adur, M. K., Keating, A. F., & Baumgard, L. H. (2017). Physiological mechanisms through which heat stress compromises reproduction in pigs. Molecular reproduction and development, 84(9), 934-945. doi: https://doi.org/10.1002/mrd.22859. Victoria Sanz Fernandez, M., Johnson, J. S., Abuajamieh, M., Stoakes, S. K., Seibert, J. T., Cox, L., Kahl, S., Elsasser, T. H., Ross, J. W., Isom, S. C., Rhoads, R. P., & Baumgard, L. H. (2015). Effects of heat stress on carbohydrate and lipid metabolism in growing pigs. Physiology Reproduction, 3(2), e12315. doi: https://doi.org/10.14814/phy2.12315. Sanz Fernandez, M. V., Stoakes, S. K., Abuajamieh, M., Seibert, J. T., Johnson, J. S., Horst, E. A., Rhoads, R. P., & Baumgard, L. H. (2015). Heat stress increases insulin sensitivity in pigs. Physiol Rep, 3(8), e12478. https://doi.org/10.14814/phy2.12478 Sebranek, J. G., Sewalt, V. J., Robbins, K. L., & Houser, T. A. (2005). Comparison of a natural rosemary extract and BHA/BHT for relative antioxidant effectiveness in pork sausage. Meat Science, 69, 289-296. doi: https://doi.org/10.1016/j.meatsci.2004.07.010. Sekretar, S., Schmidt, S., Vajdak, M., Zahradnikova, L., & Annus, J. (2018). Antioxidative and antimicrobial effects of some natural extracts in lard. Czech Journal of Food Sciences, 22, 215-218. doi: https://doi.org/10.17221/10664-CJFS. Selye, H. (1998) Syndrome produced by diverse nocuous agents. 1936. J Neuropsychiatry Clin Neurosci, 10(2), 230-1138. doi: https://doi.org/10.1176/jnp.10.2.230a Shaposhnikov, M. V., Shilova, L. A., Plyusnina, E. N., Volodina, S. O., Volodin, V. V., & Moskalev, A. A. (2016). Influence of preparations containing phytoecdysteroids and plant steroid glycosides on the life span and stress resistance of Drosophila melanogaster. Russian Journal of Genetics: Applied Research, 6(2), 215-222 (in Russian). Sirini, A. M., Amarakoon, B. K. Regulation of oxidative stress in weaned piglets challenged with Escherichia coli. (2017). A Thesis submitted to Faculty of Graduate studies of The University of Manitoba in fulfillment of the requirements of the degree of Master of Science Department of Animal Science Faculty of Agricultural and Food Sciences University of Manitoba, Winnipeg, Manitoba, Canada. Available from: http://hdl.handle.net/1993/32492/.  Spinul, A. I. (2018). Fiziologicheskie aspekty profilaktiki i metafilaktiki narushenij obmena veshchestv i snizheniya rezistentnosti organizma telyat v molochnyj period vyrashchivaniya. Thesis of Doctoral Dissertation. FGBNU “Federal'nyj nauchnyj centr zhivotnovodstva - VIZH imeni akademika L.K. Ernsta” (in Russian). Sutherland, M. A., Bryer, P. J., Davis, B. L., Smith, J. F., & McGlone, J. J. (2012). The combined effects of transport and food and water deprivation on the physiology of breeding age gilts. Livestock science, 144(1-2), 124-131. doi: https://doi.org/10.1016/j.livsci.2011.11.005. Tolkushkina, G. D. (2001). Sistema antioksidantnoy zashchity zhivotnykh pri khronicheskikh antropogennykh nagruzkakh: teoreticheskiye predposylki. Selskoye khozyaystvo Sibiri na rubezhe vekov: Itogi i perspektivy razvitiya. Novosibirsk (in Russian). Verdon, M., Hansen, C. F., Rault, J. L., Jongman, E., Hansen, L. U., Plush, K., & Hemsworth, P. H. (2015). Effects of group housing on sow welfare: a review. Journal of Animal Science, 93(5), 1999-2017. doi: https://doi.org/10.2527/jas.2014-8742. Vostroilova, G. A., Khokhlova, N. A., Lobodina, T. E., Fomenko, O. Yu., Alekhin, Yu. N., & Mikhaylov, E. V. (2015). Biokhimicheskiy i immunnyy status porosyat pri otyemnom stresse i ego farmakokorrektsiya aminoseletonom. Veterinarnaya patologiya, 1(51), 69-75 (in Russian). Wathes, C., & Whittemore, C. (2006). Environmental management of pigs. In: Kyriazakis I., Whittemore C., Whittemore C.T. (Eds.). Whitemore’s science and practice of pig production. Oxford: Blackwell Publishing, pp: 533-590. Wegner, K., Lambertz, C., Das, G., Reiner, G., & Gauly, M. (2016). Effects of temperature and temperature???humidity index on the reproductive performance of sows during summer months under a temperate climate. Animal Science Journal, 87(11), 1334-1339. doi: https://doi.org/10.1111/asj.12569. Yang, H., Xiong, X., Wang, X., Tan, B., Li, T., & Yin, Y. (2016). Effects of weaning on intestinal upper villus epithelial cells of piglets. PloS one, 11(3), e0150216. doi: https://doi.org/10.1371/journal.pone.0150216. Yu, C. H., Chen, C. Y., & Chang, C. C. (2019). The immediate effects of weaning stress on the hypothalamus???pituitary???adrenal alteration of newly weaned piglets. Journal of animal physiology and animal nutrition. doi: https://doi.org/10.1111/jpn.13104. Zeng, Y., Wang, H., Liu, Z., Li, S., Pu, S. & Long, D. (2018). Effects of ambient temperature on production performance of sows and regulatory techniques. Scientia Agricultura Sinica, 51(16), 3171-3180. doi: https://doi.org/10.3864/j.issn.0578-1752.2018.16.013. Zou, Y., Wei, H. K., Xiang, Q.-H., Wang, J., Zhou, Y.-F., & Peng, J. (2016). Protective effect of quercetin on pig intestinal integrity after transport stress is associated with regulation oxidative status and inflammation. J Vet Med Sci, 78(9), 1487-1494. doi: https://doi.org/10.1292/jvms.16-0090. Zupan, M., & Zanella, A. J. (2017). Peripheral regulation of stress and fear responses in pigs from tail-biting pens. Revista Brasileira de Zootecnia, 46(1), 33-38. doi: https://doi.org/10.1590/S1806-92902017000100006.   

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