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Amaç: Çölyak Hastalığı (ÇH) toplumun yüzde %1’ini etkileyen, diğer otoimmun hastalıklarla birliktelik gösteren ve ekstraintestinal manisfestasyonlara sahip otoimmun bir hastalıktır. Bu çalışmada 94 hastanın demografik ve laboratuvar bulgularını, kansızlık, osteoporoz ve diğer otoimmun hastalıklar ile ilişkisini araştırdık. Gereç ve Yöntem: Bu çalışma Ocak 2014-Aralık 2019 tarihleri arasında ÇH tanısı ile takipli 94 hastanın hasta kayıtları incelenerek retrospektif olarak yapılmıştır. Bulgular: Hastaların 74’ü kadın (%79), 20’si erkekti (%21). Hastaların ortalama yaşı 35 idi (18-73). Ortalama hastalık süresi 6.6 yıldı (0-29). 81 hastada anti-endomisyum Ig A pozitifliği (%86) ,87 hastada doku transglutaminaz Ig A pozitifliği (%93) ve 45 hastada doku transglutaminaz Ig G pozitifliği saptandı (%48). 14 hastada hipotiroidi (%15) ve 8 hastada diabetes mellitus (%9) saptandı. 61 hastada kemik mineral dansitometri sonucunda osteoporoz veya osteopeni saptandı (%65). Ferritin sonuçlarına göre hastaların yarısında, transferrin saturasyonunu sonucuna göre ise %47’sinde demir eksikliği mevcuttu. 13 hastada B12 eksikliği (%14), 24 hastada folik asit eksikliği mevcuttu (%26). Hastaların %74’ünde D vitamin eksikliği saptandı. 10 hastada TSH değeri 4.5 mIU/L’den büyük saptandı. Hipotiroidi oranı %10’larda iken anti-TPO antikor pozitifliği %40, anti-TG pozitifliği ise %38 idi. Sonuç: ÇH demir, folat, vitamin B12 ve vitamin D eksikliği ve bunlara bağlı kansızlık ve osteoporoz ile ilişkili olup hastalığa sıklıkla otoimmun tiroid hastalıkları ve diyabet eşlik etmektedir.
Goal: Cervical disease (CH) is an autoimmune disease that affects 1% of the population, associates with other autoimmune diseases and has extraintestinal disinfections. In this study, we studied the demographic and laboratory findings of 94 patients, the relationship with impotence, osteoporosis and other autoimmune diseases. Method and method: This study was conducted retrospective by examining the patient records of 94 patients followed by CH diagnosis between January 2014-December 2019. The findings: 74 of the patients are women (79%), 20 are men (21%). The average age of patients was 35 (18-73). The average duration of the disease was 6.6 years (0-29). In 81 patients, anti-endomy Ig A positive (86%) , in 87 patients, tissue transglutaminase Ig A positive (93) and in 45 patients, tissue transglutaminase Ig G positive (48%) were identified. Hypothyroidism was diagnosed in 14 patients (15%) and diabetes mellitus in 8 patients (9%). In 61 patients, osteoporosis or osteopenia were detected as a result of bone mineral dancithometry (65%). According to the results of Ferritin, half of patients, and 47% of patients, according to the results of transferrin saturation, had iron deficiency. In 13 patients there was a lack of B12 (14%) and in 24 patients there was a lack of folic acid (26%). 74% of patients have a vitamin D deficiency. In 10 patients, the TSH value was greater than 4.5 mIU/L. The rate of hypothyroidism was 10%, while anti-TPO antibody positive was 40%, and anti-TG positive was 38%. The result: the deficiency of iron, folate, vitamin B12 and vitamin D and associated with impotence and osteoporosis is often accompanied by autoimmune thyroid diseases and diabetes.
Aim: Celiac Disease (CD) which is an autoimmune disease affecting 1% of the population is associated with other autoimmune diseases and has extraintestinal manifestations. In the present study, we investigated the demographic and laboratory data of 94 patients and diseases related to anemia, osteoporosis and other autoimmune diseases. Material and Method: This study was conducted retrospectively by examining the records of 94 patients who were followed up with the diagnosis of CD between January 2014 and December 2019. Results: Of the patients, 74 were female (79%), 20 were male (21%). The mean age of the patients was 35 (18-73). The average disease duration was 6.6 years (0-29). Anti-endomysium Ig A positivity in 81 patients (86%), tissue transglutaminase Ig A positivity in 87 patients (93%), and tissue transglutaminase IgG positivity in 45 patients (48%) were detected. 14 patients had hypothyroidism (15%) and 8 patients had diabetes mellitus (9%). Osteoporosis or osteopenia was detected in 61 patients as the result of bone mineral densitometry (65%). According to the ferritin results, half of the patients and according to the transferrin saturation result, 47% had iron deficiency. 13 patients had B12 deficiency (14%) and 24 patients had folic acid deficiency (26%). Vitamin D deficiency was found in 74% of the patients. TSH value was found over 4.5 mIU/L in 10 patients. Conclusion: CD is associated with iron, folate, vitamin B12, and vitamin D deficiency and is associated with anemia and osteoporosis, and the disease is often accompanied by autoimmune thyroid diseases and diabetes.
Alan : Sağlık Bilimleri
Dergi Türü : Uluslararası
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