Abstract:

X-ray repair cross complementing 1 and 3 (XRCC1 and XRCC3) gene plays a key role in DNA repair, genetic instability and tumorigenesis. We hypothesized that single nucleotide polymorphisms (SNPs) in XRCC1 and XRCC3 gene might affect its expression and/or function which have an influence on the development of cervical cancer. The aim of our study was to assess the association of four polymorphisms was carried out in the following DNA repair genes: XRCC1 (Arg399Gln, Arg194Trp) (rs25487, rs1799782), XRCC3 (C241T and A316G) (rs861539, rs1799794). The study group included 505 Senegalese individuals (313 cervical cancer patients, and 192 healthy controls). From the cancer patients and controls, genomic DNA was extracted from blood and tissues samples. Genotype was carried out for four SNPs using Taqman genotyping assay method. A significant association was found between XRCC1194C>T and cervical cancer (OR= 2.696 95% CI= 1.181-6.154 p= 0.018, using an additive model), (OR=2.989 95% CI= 1.078-8.283 p= 0.035, using dominant model), while there is no significant association between Arg399Gln polymorphisms and cervical cancer. Also, no association was found between XRCC3Thr241Met genotype and expressed risk of susceptibility to both cervical cancer in Senegalese population.This study indicates that variant types of DNA repair genes play an important role in modifying individual susceptibility to cervical cancer.

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