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Polikistik Over Sendromu (PKOS) etiyolojisi karmaşık olan multifaktöriyel bir endokrin bozukluktur. Ayrıca kadınlarda obezite ve tip 2 diyabet gelişim riskini arttıran metabolik bozukluklarla da ilişkilidir. Obezite/adipozite ve insülin direnci PKOS’lu kadınlarda oldukça sık karşılaşılan bir problemdir. İnsan genomunun ayrıntılı olarak incelendiği genom projelerinde obezite ve bazı hastalıklarla ilişkili çok sayıda gen ve genetik varyasyonların bulunduğu gösterilmiştir. Bu genler içerisinde yağ kütlesi ve obezite ile ilişkili gen (FTO) ve melanokortin-4 reseptör geni (MC4R) varyantları obezite, aşırı vücut ağırlığı ve tip 2 diyabet ile ilişkilidir. Bu nedenle FTO ve MC4R genlerinin obezite/adipozite gelişimine etkileri yoluyla PKOS ile ilişkili olabileceği öne sürülmektedir. Bu derleme makalede obeziteyle ilişkili bazı gen polimorfizmlerinin (FTO ve MC4R) PKOS ile ilişkisi incelenmiştir.
Polycystic Over Syndrome (PKOS) is a multifactorial endocrine disorder that is complex in the ethology. It is also associated with obesity and metabolic disorders that increase the risk of developing type 2 diabetes in women. Obesity/adiposity and insulin resistance are a very common problem in women with PKOS. In the genomic projects in which the human genom is thoroughly studied, it has been shown that there are numerous genetic and genetic variations associated with obesity and some diseases. The variants of the fat mass and obesity-related genes (FTO) and melanocortin-4 receptor genes (MC4R) in these genes are associated with obesity, excess body weight and type 2 diabetes. Therefore, it is suggested that FTO and MC4R genes may be associated with PKOS through their effects on the development of obesity/adiposity. This collection article examined the relationship of some gen polymorphisms (FTO and MC4R) associated with obesity with PKOS.
Polycystic Ovary Syndrome (PCOS) is a multifactorial endocrine disorder with a complex etiology. It is also associated with metabolic disorders that increase the risk of developing obesity and type 2 diabetes in women. Obesity / adiposity and insulin resistance is a common problem in women with PCOS. Genome projects, which examine the human genome in detail, have been shown to have a large number of genes and genetic variations associated with obesity and some diseases. Among these genes, fat mass and obesity-associated gene (FTO) and melanocortin-4 receptor gene (MC4R) variants are associated with obesity, excess body weight, and type 2 diabetes. Therefore, it is suggested that genes, FTO and MC4R, may be associated with PCOS through the effects of obesity / adiposity development. In this review article, the relationship of some obesity-related gene polymorphisms (FTO and MC4R) with PCOS has been investigated.
Alan : Sağlık Bilimleri
Dergi Türü : Uluslararası
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