Abstract:

To investigate serum HLA-G levels and its correlation with oxidative stress and antioxidant parameters in breast cancer patients. Materials and methods: The patient group consisted of 25 individuals with breast cancer who were operated on in the General Surgery Department of Gazi University’s Faculty of Medicine. Thirty-one individuals who had no history of any kind of cancer, allergic diseases, diabetes, or rheumatic and immunological disease constituted the control group. Results: Results showed that malondialdehyde (MDA), advanced oxidation protein products (AOPPs), and HLA-G levels in the patient group were statistically and significantly high compared to the control group (P < 0.001). While vitamin C levels were significantly lower in the patient group (P < 0.05), an insignificant difference in glutathione peroxidase (GPx) and total sulfhydryl group (R-SH) levels in both groups was observed (P > 0.05). Serum superoxide dismutase (SOD) levels in the patient group were significantly low compared to the control group (P < 0.001). In the control group, statistically significant positive correlations among HLA-G, MDA (r = 0.580, P = 0.001), and AOPP (r = 0.569, P = 0.01) were observed. In the control group, a significant positive correlation in MDA and AOPP levels (r = 0.482, P = 0.006) was observed. Conclusion: Results of the present study indicated that there was a relationship between the oxidative stress and the deficiency of antioxidant defenses as lipid peroxidation, protein oxidation, and HLA-G expression increased.

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