Özet:

Objective: To investigate the effects of carbamazepine therapy on thyroid function tests in children Methods: The carbamazepine group consisted of 58 children under observation for epilepsy, and the control group of 54 healthy children. Age of onset, length of drug use, drug dosage and laboratory parameters including free triiodothyronine (FT3), free thyroxin (FT4) and thyrotropin (TSH) were recorded. These data were then compared against those from the control group. Results: In the carbamazepine group, FT3 was 3.86 ± 0.43 pg/mL, FT4 was 1.15 ± 0.18 mg/dL and TSH: 2.58 ± 1.33 ml U/L. In the control group, FT3 was 4.13 ± 0.59 pg/mL, FT4 1.34 ± 0.13 mg/dL and TSH was 2.06 ± 0.89 ml U/L. No statistically significant difference between rates of subclinical hypothyroidism was determined between the two groups (p=0.196). Conclusion: Although, carbamazepine reduces thyroid hormone concentrations, rarely causes hypothyroidism.

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