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ÖZET Giriş: Bu çalışmada epitelyal over kanserlerinden rezeke edilen tümör spesmenlerinde, CD 44 ve CD 24’ün ekpresyonları analiz edilerek, bu ekspresyon ve klinikopatolojik parametreler arasındaki ilişkiyi analiz edilmiştir. Gereç Ve Yöntemler: Bu çalışma, Kliniğimizin Jinekolojik Onkoloji Anabilim Dalı'nda tedavi edilen primer over kanseri olan 31 hastayı içermektedir. Bulgular: Anti-CD24 için incelenen 14 seröz karsinomlu spesmende 6 örnekte şiddetli (+++) immünoreaktivite, 4 örnekte orta / şiddetli (++ / +++) immünoreaktivite, 2 numunede orta / şiddetli (++ / +++) immünoreaktivite, 2 örnekte hafif / orta (+ / + +) immünoreaktivite gözlendi. Bu 14 hasta CD 44 için incelendiğinde 3 örnekte (++) modereta immünoreaktivitesi, 2 örnekte + / ++ (hafif / orta) immünoreaktivite, 9 örnekte + (hafif) immünoreaktivite gözlendi. Sonuç: CD44 immünoreaktivitesinin boyanma yoğunluğunun over epitelyal kanserlerinde sağkalım oranı ile ilişkili olduğu, ancak istatistiksel olarak anlamlı olmadığı tespit edildi. Her ne kadar CD 24 sağkalımı ile ilişkinin istatistiksel olarak anlamlı bulunmamasına rağmen, Over tümörlerde tanısal bir belirteç olarak kullanılabileceği düşünüldü. Anahtar Kelimeler: Cd-24 Cd-44 Immünohistokimya Over Kanseri. ABSTRACT Objective: The present study evaluated the CD24 and the CD44 expression in resected tumor specimens of ovarian carcinom and analyzed the correlation between this expression and the clinicopathological parameters. Material Methods: The present study included 31 patients with primary ovarian cancer who were treated in the Department of Gynecologic Oncology of our Clinic Results: 14 serous carcinomas examined for anti-CD24 severe (+++) immunoreactivity was observed in 6 samples, moderate / severe (++ / +++) immunoreactivity was observed in 4 samples, moderate (++) immunoreactivity was observed in 2 samples and mild / moderate (+ / ++) immunoreactivity was observed in 2 samples. When these 14 patients were examined for CD 44 (++) modereta immunoreactivity was observed in 3 samples, + / ++ (mild / moderate) immunoreactivity was observed in 2 samples and + (mild) immunoreactivity was observed in 9 samples. Conclusion: It was determined that the staining intensity of CD44 immunoreactivity was related to the survival rate in ovarian epithelial cancers, but it was not statistically significant. Although the association with survival of CD 24 was not found to be statistically significant, it was thought that it could be used as a diagnostic marker in over-tumors. Key words: CD24 CD44 Immunohistochemistry Ovarian tumor
INTRODUCTION: In this study, the tumor sperm scratched from epithelial over cancers, the CD 44 and CD 24 expressions were analyzed, and the relationship between this expression and clinic pathological parameters was analyzed. Tools and Methods: This study included 31 patients with primary over cancer treated in the Clinic’s Gynecological Oncology Anabolic Department. Results: 14 serous carcinoma spesmen studied for Anti-CD24; severe (+++) immune reaction in 6 samples, medium / severe (++ / +++) immune reaction in 4 samples, medium / severe (++ / +++) immune reaction in 2 samples, light / medium (+ / + +) immune reaction in 2 samples. When these 14 patients were studied for CD 44; in 3 samples (++) modereta immune reaction, in 2 samples + / ++ (light / medium) immune reaction, in 9 samples + (light) immune reaction was observed. The result: the coloring intensity of CD44 immunoreactivity was found to be related to the survival rate in over epithelial cancer, but it was not statistically meaningful. Although the relationship with CD 24 is not statistically meaningful, it was thought that it could be used as a diagnostic indicator in over tumors. Keywords: Cd-24; Cd-44; Immunohistochemistry; Over Cancer. ABSTRACT Objective: The present study evaluated the CD24 and the CD44 expression in resected tumor specimens of ovarian carcinoma and analyzed the correlation between this expression and the clinicopathological parameters. Material Methods: The present study included 31 patients with primary ovarian cancer who were treated in the Department of Gynecologic Oncology of our Clinic Results: 14 serous carcinomas examined for anti-CD24; levels (+++) immunoreactivity was observed in 6 samples, moderate / levels (++ / +++) immunoreactivity was observed in 4 samples, moderate (++) immunoreactivity was observed in 2 samples and mild / moderate (+ / ++) immunoreactivity was observed in 2 samples. When these 14 patients were examined for CD 44; (++) modereta immunoreactivity was observed in 3 samples, + / ++ (mild / moderate) immunoreactivity was observed in 2 samples and + (mild) immunoreactivity was observed in 9 samples. Conclusion: It was determined that the staining intensity of CD44 immunoreactivity was related to the survival rate in ovarian epithelial cancers, but it was not statistically significant. Although the association with survival of CD 24 was not found to be statistically significant, it was thought that it could be used as a diagnostic marker in over-tumors. Key words: CD24; CD44; Immunohistochemistry; Ovarian tumor
Alan : Sağlık Bilimleri
Dergi Türü : Uluslararası
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