Özet:

Purpose: Adriamisin is a wide spectrum cancer drug used in the treatment of many solid tumors and hematological malignities. It is known that the main side effects of the use of Adriamisin are heart failure and cardiomyopathy. Studies have shown that oxidative stress plays an important role in the pathogenesis of cardiotoxicity of adriamis. Nesfatin-1 has a close relationship with diabetes, obesity, anorexia nervoza, psychiatric disorders and neurogenic diseases. It has been that Nesfatin-1 directly affects myocardial performance and protects the heart muscle from damage to ischemic reperfusion. The tool and method: In our study, adult Wistar albino male rats were used. The animals were divided into two groups, including six animals. No process was carried out to the control group for 14 days of the test period. The group of Adriamisin was given 10 mg/kg/one dose of Adriamisin intraperitoneally. At the end of the test, the rats were decaptivated under anesthesia and the heart tissues were removed. With routine protocols, the tissues are buried in paraffin blocks. The method of avidin-biotin-peroxidase was applied to the cuts for the immune reaction of Nesfatin-1. The frequency of cytoplasmic immune painting was scored semi-quantitatively with numbers from 0 to +3. Results: Immunreactivity of Nesfatin-1 was observed at +3 frequency in myocytes in the cardiovascular tissue in the control group. Compared to the control group, there was a significant decrease in myocytes in the adriamisine group in the immune reaction of nesphatin-1 and the prevalence of +1 was detected. The result: We believe that there is a discharge of nesphatin-1 in the rats' heart tissue, that the application of experimental adriamis reduces the immune reactiveness of nesphatin-1 in the rats' heart tissue, and that this can also be caused by the damage and/or loss of myocytes associated with adriamis.

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