Özet:

Introduction and purpose: Metalloproteinases (MMP) have an increasing attention in the pathogenesis of respiratory distress syndrome (RDS) that is frequently seen in preterm babies. MMPs are included in the structure and function of extracellular matrix and basal membrane and in the destruction of some structural elements. They are inhibited by specific tissue metalloproteinase inhibitor (TIMPs). In previous studies, changes in MMP 2-8-9 and TIMP-2 levels were reported. We aimed to detect MMP 2-8-9 and TIMP-2 levels in serum samples of preterm babies with RDS. Material and methods: Study group was formed by 24 RDS patients under 37 weeks of gestational age according to the new Ballard scale. Twenty-one baby without respiratory distress and any additional problem was established as control group. MMP-2, MMP-8, MMP-9 and TIMP-2 levels were studied in 2 cc blood samples which were collected in the first 48 hours of delivery of all included babies. Results: No significant difference was found between the levels of MMP 2-8-9 and TIMP-2 in study and control groups.Conclusion: Further studies are needed to suggest that there is no difference of MMP and TIMP levels in mild-moderate grade RDS patients.

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