Özet:

Intrahepatic cholestasis of pregnancy (ICP) is the most frequently encountered pregnancy-specific hepatic disease that may cause obstetric complications such as spontaneous premature birth, fetal distress, meconium-stained amnion fluid and stillbirth. This study aimed to retrospectively analyze the pregnancy and fetal outcomes of patients who were diagnosed with ICP. Material and Method: In the retrospective case study, pregnant women who visited with the complaint of itching between November 2017 and September 2019 and had constant itching and increased even acids in the maternal blood (≥10 μmol/L) without any liver or skin pathology were accepted as ICP. For the 44 cases that were included in the study, demographic characteristics, liver enzymes, week of pregnancy at diagnosis, duration of exposure to the disease, type of delivery, time of delivery, APGAR scores and the weight of the newborn were collected from the hospital records. Results: The average age of the participants was 26.77±6.23, while 61.4% were nulliparous. The average time of diagnosis was 35,52±1,72 weeks, while the average week of pregnancy was 36,64±1,78. The average duration of exposure to the disease was calculated as 7.54±8.14 days. 17 of the pregnant women (38.6%) gave birth via normal vaginal delivery, while 27 (61.4%) gave birth by Cesarean section delivery. Pregnancy complications were found as premature birth (n=1), gestational diabetes (n=1) and preeclampsia (n=1). There was no in utero fetal death. Intrahepatic cholestasis of pregnancy causes significant maternal and fetal complications. Close monitoring and active management are required in the prevention of these complications.

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