Abstract:

Aim: The aim of this study was to determine the usefulness of systemic immune-inflammation index (SII) in the diagnosis of acute appendicitis (AA) in children Material and Method: This study was done retrospectively, and two groups were formed as AA and control group. AA group was divided into two subgroups as nonperforated appendicitis and perforated appendicitis. The groups were compared for age, sex, WBC, neutrophil, lymphocyte and platelet count, neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), systemic immune-inflammation index (SII), C-reactive protein (CRP). Results: The study included a total of 162 children. There were 81 children in the AA group and 81 in the control group. Of 81 patients included in the AA group, 31 were girls (38.3%) and 50 were boys (61.7%), and the median age of the patients was 11 (5) years. When the AA group and the control group were compared in terms of laboratory values. It was found that WBC count, neutrophil count, platelet count, NLR, PLR and SII in the AA group were significantly higher and lymphocyte count was significantly lower (p<0.001 for all). When nonperforated and perforated appendicitis groups were compared, there was a significant difference only in CRP value and the CRP value was significantly higher in the perforated appendicitis (groups p<0.001) Conclusion: To the best of our knowledge, present study is the first report to demonstrate the diagnostic value of SII in children with AA. We think that SII can use as novel marker supporting AA diagnosis in children

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