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Objectives: In this study, we aim to compare the results of aspiration of thyroid nodules evaluated according to the Bethesda category (BC) with tissue diagnoses in the operation materials and to compare the sensitivity, specificity and accuracy rates according to cytology methods. Methods: The previous fine-needle aspiration biopsy (FNAB) of thyroid nodules of 879 cases diagnosed histopathologically between 2010 and 2017 was examined. The FNAB results determined according to the Bethesda system were matched with tissue diagnoses, sensitivity, specificity, and accuracy rates were investigated according to cytology methods. Results: Sensitivity, specificity, Positive predictive value (PPV), Negative predictive value (NPV) and accuracy rates were found in all FNAB results (in units of %; Sensitivity; 84.7, Specificity; 81.1, PPV; 74.1, NPV; 89.2, Accuracy; 82.5). All of the cytological evaluation methods of thyroid FNABs were found to be reliable and effective (Generally, the results are 80% and above). Specificity and accuracy rates were close to the general average (82.5%) in all methods. However, in cases evaluated with liquid base cytology (LBC) method and in addition to LBC or conventional smear (CS), the sensitivity rates in cases where cell block (CB) were evaluated together were higher than cases in which LBC and CS were used alone (92.6% and 91.0%). When examined statistically, there was no significant difference concerning sensitivity, specificity and accuracy rates of cytological methods (p>0.05, respectively, p=0.576, 0.065, 0.643). Conclusion: In cytopathology, when evaluating thyroid aspirations, it is seen that the LBC method is used instead of CS. In our study, we recommend the use of the LBC method, which seems to have the highest sensitivity (taking into account its technical advantages), instead of CS. However, we think that both CS and LBC methods should be evaluated by supporting them with cell block sections.
Purpose: Assessed according to the Bethesda category, it is to compare the aspiration results of the thyroid nodes, the precise tissue diagnoses after the surgical materials, as well as according to the methods used in cytology, to determine the sensitivity, specificity and accuracy rates. Method: The results of the thin injection aspiration biopsy (IAB) from the thyroid nodes of 879 incidents, which were operated between 2010-2017 years, with histopathologically confirmed tissue diagnosis, were compared. The IAB results determined according to the Bethesda system were matched with tissue diagnoses, the sensitivity, specificity, accuracy rates were determined and compared according to the cytological methods. Results: In all IIB results, sensitivity, specificity, positive forecast value (PPV), negative forecast value (NPV) and accuracy rates were found (in the percentage unit; Sensitivity; 84.7, specificity; 81.1, PPV; 74.1, NPV; 89.2, accuracy; 82.5). All of the cytological assessment methods of thyroid IABs were found at reliable and effective rates (in general, the results are 80% and above). The frequency and accuracy rates, in all methods, were close to the overall average (82.5 percent). However, in fluid-based cytology (SBS) methods and in addition to SBS or conventional spread (KY), the sensitivity rates in cases where the cell block (HB) was evaluated together were higher than in cases where SBS and KY were used alone (% 92.6 and% 91.0). Statically, there was no significant difference in the sensitivity, specificity and accuracy ratio of cytological methods (p>0.05, respectively, p=0.576, 0.065, 0.643). Result: In cytopathology, it is seen that when assessing thyroid aspirations, the use of the SBS method instead of KY is placed. We also recommend the use of the SBS method, which is considered to be the highest sensitivity (with regard to its technical advantages), instead of KY in our study. But we think it is necessary to evaluate the need for KY, the need for SBS method, in addition to supporting the cells block cuts. (SETB 2020-10-208)
Alan : Sağlık Bilimleri
Dergi Türü : Ulusal
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