Abstract:

HUMAN CHITINASE-3-LIKE PROTEIN: A PATHOGENIC ROLE IN RECURRENT IMPLANTATION FAILURE? Human Chitinase-3-like Protein 1 (CHI3L1) alias serum human cartilage glycoprotein 39 (YKL- 40) is a new biomarker frequently associated with cancer and inflammatory diseases. Hematological parameters also can be called as sensitive markers of inflammation including mean platelet volume (MPV) and systemic inflammatory response (SIR) markers [neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR)]. In this paper, it was aimed to examine the levels of CHI3L1, MPV, NLR and PLR in patients with recurrent implantation failure (RIF) and compare them with healthy women with proven fertility. The study group consisted of 28 infertile women with RIF charectirized as a failing to attain a clinical pregnancy after three consecutive cycles of IVF or ICSI. In these processes, first, all embryos must be valuable and sufficient experimental phase – second, the total number of transferred ones was at least four cleavages –stage embryos and minimum two for blastocysts as well. The control group included 28 healthy women with proven fertility that had conceived spontaneously and not lost a pregnancy. Hematological parameters were automatically calculated. Irrevelant differences were revealed among the groups with regard to age and body mass index. Whereas Human Chitinase-3-like Protein 1 levels were similar in RIF (59.6 (38.6-421.2 ng/ml)) and control subjects (68.5 (20.6-486.4 ng/ml)) (p=0.222). insignificant differences were resulted in MPV, NLR and PLR. Recurrent implantation failure was not associated with altered CHI3L1, MPV, NLR and PLR levels. Key words: Human Chitinase-3-like Protein 1, recurrent implantation failure, neutrophil-lymphocyte ratio, platelet-lymphocyte ratio

Keywords: