Özet:

Objective: Autoanticors such as the Romatoid factor, anti-nuclear antibodies, anti-Ro/SSA and anti-La/SSB play an important role in the diagnosis of primary Sjögren syndrome (PSS), but it is not necessary for seronegative PSS diagnosis when there is at least one focus in the microscopic sperm biopsy. In this study, clinical and serological differences between patients with seropositive and seronegative PSS were studied. Tools and Methods: June 2018-July 2021 was included in the study of 273 patients with PSS followed in Kayseri City Education and Research Hospital, a third-level hospital between the dates. PSS diagnosis, 2016 American College of Romatology/European League against Romatism PSS classification criteria have been determined. Thirty and fifty (% 16). 5) the patient was not identified with autoanticor and these patients were considered seronegative PSS. The clinical and laboratory parameters of patients were collected backward from the hospital database. Clinical and laboratory data of patients with seronegative and seropositive PSS were compared. Results: Seropositive group was 214 (93.9%) and seronegative group was 41 (91.1) female patients. The average diagnosed age was 47.87±9.07 years for seropositive and 44.34±11.48 years for seronegative (p=0.026). There is no statistically meaningful difference between seronegatives and seropositives in terms of gender distribution, clinical characteristics and the number of patients with a rise in locopene, lymphopene, trombocytopene, hypergamaglobulinemia, hypokomplementemia and acute phase reactor. In the seropositive PSS group, the C4 median value was lower, the IgG median value was higher. Results: Clinical findings in patients with seronegative PSS are combined with findings in patients with seropositive PSS, but later diagnosed in patients with seronegative PSS.

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