Özet:

Immunoglobulin A vasculitis (IgAV) is the most common small vein vasculitis in childhood. The palpable purpura is a characteristic feature seen in the lower limbs. It is also quite common to affect joint pain, arthritis, the gastrointestinal system (GIS) and the urinary system. The majority of hospitalization is due to the cause of GIS shutdown. In this study, we tried to identify the risk factors for GIS retention in IgAV. NEED AND METHOD: In September 2015-August 2020, the records of a total of 100 patients with and non-GIS infection monitored with IgAV diagnosis in our hospital's child-romatology clinic were retrospective examined. Clinical, demographic, laboratory parameters and the therapies applied were recorded. Foundations: 100 (49 K/51 E) patients were selected from patients with GIS and the other half were not with GIS. The average diagnosis age was 8 (6.1-9.8) years. All patients had palpable purpura. Other most common findings were arthritis (34%) and arthritis (52%). All of the patients who suffered from a stroke had a pain in the stomach. Active bleeding occurred in 25% of patients with GIS (n=12). There is no relationship between age, gender, other clinical findings, seasonal differences, laboratory parameters at the moment of diagnosis between patients with and not with GIS. However, the presence of MEFV gen mutation was more frequently detected in the group with severe GIS retention (p=0,009). Renal attitude developed in 18% of patients. All of the patients were healed without complications. The result: GIS shutdown in IgAV is quite frequent. In this study, we showed that differences such as age, gender, distribution of other clinical findings, seasons are not a determining factor for GIS holding. However, it should be taken into account that MEFV gene mutations may contribute to patients with severe GIS constipation. Immunoglobulin A vasculitis (IgAV) is the most common small vasculitis in childhood. It is characteristic of palpable purpura seen in the lower extremities. Also, joint pain, arthritis, gastrointestinal system (GI) and urinary system involvement are quite common. Especially most hospitalizations are due to GI involvement. In this study, it was aimed at determining the risk factors for GI involvement in IgAV. The files of 100 patients with and without GI involvement who were followed up with a diagnosis of IgAV in the pediatric rheumatology department of our hospital between September 2015 and August 2020 were retrospectively analyzed. Clinical, demographic, laboratory parameters and applied treatments were recorded. Results: Half of the 100 (49 F/51 M) patients were selected from patients with GI involvement and the other half from patients without GI involvement. The median age of diagnosis was 8 (6.1-9.8) years. All patients had palpable purpura. The other most common findings were arthritis (34%) and arthralgia (52%). All patients with GI involvement had abdominal pain. Active bleeding was present in 25% (n = 12) of the patients with GI involvement. No relationship was found between patients with and without GIS involvement, between age, gender, other clinical findings, seasonal differences, and laboratory parameters at the time of diagnosis. However, the presence of MEFV gene mutation was detected more frequently in the group with level GI involvement (p = 0.009). Renal involvement developed in 18% of the patients. All the patients recovered without any complications. CONCLUSION: GI involvement is very common in IgAV. In this study, we showed that differences in GI involvement such as age, gender, distribution of other clinical findings, and seasons are not determinative factors for GI involvement. However, it should be kept in mind that MEFV gene mutations may contribute to patients with levels of GI involvement. Key words: IgA vasculitis, gastrointestinal system, risk, MEFV gene

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