Abstract:

Dyslipidemia is one of the complications of diabetes mellitus (DM) that can lead to elevated total cholesterol, TG, and LDL. Increased SGOT-SGPT indicates damage of hepatic cells. Black garlic extract (Allium sativum L.), which contains polyphenol, flavonoid, and anthocyanin is thought to improve blood glucose, lipid profile, and SGPT-SGOT in human. This study aimed to observe the effect of black garlic extract on blood glucose, lipid profile, and SGPT-SGOT of Wistar Rats Diabetes Mellitus Model. This study was held in 2017 at Biomedical Lab Medical Faculty of Muhammadiyah Malang University. This was a true experimental study with post test only control group design. The rats were assigned to a positive control group and 3 treatment groups consisting of 6 experimental animals each and treatment was given for 25 days. Blood glucose lipid profile, and SGPT-SGOT levels were measured by a spectrophotometer. Data were analyzed using one-way ANOVA, Post Hoc Bonferroni, and Linear Regression tests. Differences were between different groups of rats (p=0,000) with a significant difference seen between all treatment groups and the control group based on  the Post Hoc Bonferroni test results (p=0.000). Black garlic extract reduced blood sugar by 91.4%, total cholesterol by 79.1%, TG by 69.5%, LDL by  81.3%, SGPT by 91.4%, and SGOT by 70.6%. This effect is seen across doses starting from 1.5 mg/200gBW to the highest dose of 6 mg/200gBW. It can be concluded that Black garlic extract (Allium sativum L.) affects  blood glucose, lipid profile, SGPT, and SGOT positively in male wistar (Rattusnorvegicus) rats diabetes mellitus model by decreasing blood sugar, lipid profile, SGPT, and SGOT levels.

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