Abstract:

Background: Cervical cancer is the first gynecological cancer in Senegal with 1,195 new cases per year and an annual mortality of around 66% (LISCA, 2019). Mitochondrial involvement in the process of apoptosis and tumorigenesis has been analyzed previously from different cancer, and from analyses, 21 sites polymorphisms of the Cox genes (including CoxI, CoxII and CoxIII) contributed to dysfunction of mitochondrial respiratory function and have been associated with sensitivity to cancers such as prostate cancer(Green, 1998)(Cavali and Liang, 1998). These data stimulated interest in examining the potential role of mtDNA mutation of host inprogression and maintenance to cancer stades.The aim of thisstudy is to analyse the polymorphism of COXI gene from biopsies of cervical cancer in Senegalese subjects.

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