Özet:

CD4/CD8 T lymphocytes are shown in many studies in patients with mycosis fungoides (MF). It is that the matrix in the tissue has a parallel relationship between the height and tumor spread at the level of metalloproteinase (MMP). This study aims to evaluate changes in the levels of MMP-9, which are indicators of CD4, CD8 and tumor invasion of MF patients before and after treatment. The study included examples of biopsy at Selçuk University, Meram Faculty of Medicine, Deri and Zührevi Diseases Anabolic Department with 32 patients diagnosed with pathological MF in the plaque stage and 10 control patients diagnosed with non-specific chronic dermatosis. Phototherapy was applied to all MF-defined patients for 3 months, and at the end of 3 months the control biopsy was taken. Twenty patients were not identified in favour of the MF, while 12 patients were identified in pathologically compatible with the MF. For the histopathological examination of Selçuk University Meram Faculty of Medicine, a sufficient number of cuts were taken in the Department of Pathology and the control groups, as well as immunohistochemical paintings were applied to the patient groups with pre- and post-treatment MF, CD4, CD8 and MMP9. The study found that those who did not benefit from the treatment had significantly high levels of epithelial CD4/CD8 and intraepithelial MMP9. In those who were beneficial from the treatment, the epithelial and six CD4/CD8 values and the epithelial MMP-9 values were significantly low after treatment. The levels of CD4/CD8 and MMP-9 were significantly high in the MF patients according to the control group, and a decrease in the benefits of treatment was observed. In light of all the findings, the study contained results that showed parallel with literary information.