Abstract:

Purpose: The average volume of thrombocytes (MPV) is one of the important parameters of the thrombotic size that is commonly used and is a potential indicator of the reactivity of thrombocytes. Clinical and histopathological correlations with MPV have been shown in most diseases. In this study, we aimed at exploring the relationship between hepatic histopathology and the levels of MPV associated with the number and activity of thrombocytes in viral hepatitis. In our clinic, we conducted a retrospective case control study through some histological and clinical parameters of patients diagnosed with chronic hepatitis B (KHB) and chronic hepatitis C (KHC). Patients were divided into two groups: KHB and KHC. These groups were subsequently divided into groups consisting of histological activity index (HAI) and fibrosis scores according to hepatic biopsy results. Clinical characteristics of chronic viral hepatitis patients, including demographic, laboratory and hepatic biopsy findings, were evaluated. Results: The study found a statistically significant difference between the levels of MPV and trombocyte distribution width (PDW)/MPV between the HAI classes in patients with KHB and KHC (p <0,001). In patients with chronic hepatitis B, a statistically significant difference between the fibrosis classes has been found in terms of MPV and PDW/MPV levels (p <0,001). In patients with chronic hepatitis C, a statistically significant difference between the fibrosis classes has been found in terms of MPV and creatine levels (respectively p = 0,032, p = 0,042). The result: it can be used as a predictive parameter in MPV, KHB and KHC patients, treated by a simple method such as full blood counting. Therefore, the study of the correlation between MPV levels and KHB and KHC with broader prospective studies is necessary to confirm these findings.

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