Özet:

OBJECTIVE: Type 1 diabetes mellitus (T1DM) is an autoimmune disease that can affect immunologic response to vaccines by its effects on the immune system. We aimed to investigate hepatitis A (HA) and hepatitis B (HB) seroprevalences in patients with T1DM. MATERIAL AND METHODS: We included 144 patients with T1DM and 58 patients in control group between the ages of 1 and 18 who have been followed up in the Pediatric Endocrinology Clinic of Konya Training and Research Hospital between January 2014 and January 2017. We have recorded the age of the patient, diabetes diagnosis time, HBsAg, anti-HBs, anti-HAV IgG and HbA1c results from records of the patients retrospectively. RESULTS: The median anti-HBs levels (14,8 mIU/ml [interquartile range (IQR): 4,2- 100] and 37,7 mIU/ml [IQR: 7,16- 122,7], p=0,026), median anti-HAV IgG levels (11 mIU/ml [IQR: 9,88- 21,7] and 19,8 mIU/ml [IQR: 15,2- 80], p <0,001), hepatitis B virus (HBV) seropositive patient rate (%59 and %73,7, p=0,048) and hepatitis A virus (HAV) seropositive patient rate (%27,5 and %44,2, p=0,027) were low in patients with T1DM comparing to patients in control group. We have found no correlation between anti-HBs, anti-HAV IgG levels and age, duration of diabetes and HbA1C levels. CONCLUSIONS: The findings of low anti-HBs, anti-HAV IgG levels, HAV and HBV seropositive patient rates in patients with T1DM demonstrated that immunologic responses to HAV and HBV vaccines were insufficient. Given the facts that patients with T1DM have various risk factors for HBV exposure, HA infection in advanced ages result in increased complication risk, poor glycemic control with infections and low HAV and HBV seropositivity rates in T1DM patients, we need to test T1DM patients for HAV and HBV serology, vaccinate the seronegative patients and monitor the vaccine response.