Özet:

Pseudomonas aeruginosa is a Gram-negative, opportunistic pathogen that causes acute and chronic infections in immunocompromised patients. P. aeruginosa controls the production of virulence factors and biofilm formation properties with the Quorum sensing (QS) communication system, which is a kind of intercellular communication system. Studies have been carried out on the control of pathogenic bacteria by blocking or directing this communication system with different synthetic or natural molecules. Herbal essential oils, which have antibacterial, antifungal and antiviral activities because of their active molecules, have great potential in this sense. In this study, the inhibitory effects of rose essential oil, its major components (citronellol, geraniol, and nerol), and a combination of these three components (CGN) on the intercellular communication (QS) system of Pseudomonas aeruginosa PA01 strain were investigated. As a result of the study, it was determined that rose essential oil inhibited the swarming motility for the P. aeruginosa PA01 strain by 83%, and the inhibition by citronellol, geraniol, nerol, and a mixture CGN was in the range of 61-75%. For P. aeruginosa PA01 strain, biofilm formation was suppressed by rose essential oil by 54-68%, citronellol, geraniol, nerol, and mixture CGN by 10-15%. It was important that rose essential oil inhibited the swarming motility and biofilm formation of P. aeruginosa at a higher rate than the essential components of rose oil. The results of this study showed that citronellol, nerol, geraniol, and CGN had anti-QS activity for P. aeruginosa strain, but rose essential oil had a potential to be used in various applications.

Anahtar Kelimeler: