Özet:

The study was conducted in order to identify the effects of grape oil on the cardiotoxicity of docsorubin (DOX) in rats. In the study, the rats are divided into 4 groups: 1. Group: Control group, 2. Group: Applicated group of peanut butter oil (2 mL/kg/day, 7 days), 3. Group: DOX applied group (20 mg/kg body weight, i.p. One and four. Group: DOX (20 mg/kg body weight, i.p. Single dosage) + grapefruit oil (2 mL/kg/day, 7 days) is the group applied. The application of garlic oil began 2 days before the DOX application and continued for a period of 7 days. At the end of the study, the activity of antioxidant enzymes, such as malondialdehyd (MDA), low-glutation (GSH) levels in the heart tissue and catalase (KAT), glutation peroxidase (GSH-Px), superoxid dismutaz (SOD) and glutation-S-transferase (GST), was determined. In the DOX group, an increase in the levels of MDA (P<0.001) and GSH (P<0.001) compared to the control group, a decline in KAT (P<0.001), GSH-Px (P=0.024) and GST (P<0.001) activities, and no statistically significant difference in SOD activity was observed. Compared to the DOX group, the DOX+corn grass observed that the MDA, GSH levels and KAT, GSH-Px and GST activities in the DOX group reached the control group values. As a result, it has been shown that wheat oil protects the heart tissue against oxidative damage caused by DOX, a powerful chemotherapeutic drug.

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