Özet:

Giriş Overactivation of maternal immune system or high concentrations of trophoblast-derived cytokines may be responsible for the onset of first trimester pregnancy pathologies, including hyperemesis gravidarum. However, to our knowledge, there is no study evaluating maternal serum cytokine levels in patients with hyperemesis gravidarum. in the present study, we evaluated maternal serum concentrations of IL-1B, IL-2R, IL-6, IL-8, and TNF-a levels in patients with hyperemesis gravidarum and compared the levels with those in the healthy pregnant and non-pregnant women. Yöntem   Whirty women with hyperemesis gravidarum, 30 women with healthy pregnancies in the first trimester, and 30 non-pregnant women were enrolled in the study, prospectively. Maternal serum IL-1b. IL-2R, IL-6, IL-8, and TNF-a levels were evaluated using two-site chemiluminescent enzyme immuneometric assay method in the three study groups. Bulgular There was no significant difference in median matemal serum IL-2R and IL-8 levels within the three groups. in healthy pregnant patients, serum levels of IL-1b and IL-6 were significantly higher than that in the non-pregnant women. Median (range) TNF-a levels were significantly higher in hyperemesis group than the levels in healthy pregnant and non-pregnant women [25.8 pg/ml (4.9-140) vs. 10.85 pg/ml (4.1-35.8); 25.8 pg/ml (4.9-140) vs. 12 pg/ml (4.3-68.2)]. Sonuç We found significantly elevated TNF-a levels in patients with hyperemesis gravidarum compared the levels in healthy pregnant and non-pregnant women. Elevated TNF-a levels may play a role in the etiology of hyperemesis gravidarum.

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