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The Combination Effect of Ferulic Acid and Gemcitabine on Expression of Genes Related Apoptosis and Metastasis in PC-3 Prostate Cancer Cells
2018
Journal:  
European Journal of Biology
Author:  
Abstract:

DOI: 10.26650/EuroJBiol.2018.0003 Objective: Prostate cancer is the second most common cause of cancer-related deaths in men. Nowadays, new treatment approaches have been tested for cancer therapy including natural compounds with low toxicity. Ferulic acid (FA) is known as an abundant phenolic compound found in various fruits and vegetables. As a potent antioxidant, the anticarcinogenic effect of FA has been demonstrated in various cancer cell lines. The objective of this study was to investigate the combined effect of FA and gemcitabine on apoptosis and metastasis in PC-3 human prostate cancer cell lines. Materials and Methods: Cell viability was determined using the XTT method after the cells were treated with gemcitabine or FA and gemcitabine. According to the results of cytotoxicity assays, PC-3 cells were treated with

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European Journal of Biology

Field :   Fen Bilimleri ve Matematik

Journal Type :   Uluslararası

Metrics
Article : 243
Cite : 214
2023 Impact : 0.02
Details
European Journal of Biology