Abstract:

Objective: to study the relationship of gene polymorphisms of the b-adrenoreception system with the risk of atrial fibrillation in patients with heart failure. Material and methods. 286 patients with heart failure on the background of post-infarction cardiosclerosis were included. Of these, 25 (8.7 %) patients had the atrial fibrillation. The genotyping was performed using 4 polymorphisms (Gly389Arg of the b1-adrenoreceptors gene, Ser49Gly of the b1-adrenoreceptors gene, Gln27Glu of the b2-adrenoreceptors gene and Ser275 of the b3-subunit of G-protein gene) using the polymerase chain reaction. The genetic and epidemiological analysis was carried out using the SNPStats program. Results. Patients with heart failure with the G / C genotype of Gly389Arg polymorphism of the b1-adrenoreceptors gene have a lower risk of developing atrial fibrillation (OR=0.14 (0.03–0.61), p=0.0043, co-dominant model of heredity). The data on a decrease in the risk of atrial fibrillation in patients with heart failure and with the G/C genotype Gly389Arg polymorphism of the b1-adrenoreceptors gene are also confirmed in the overdominant (OR=0.15 (0.03–0.64), p=0.0012), as well as in the dominant (OR=0.23 (0.08-0.69), p=0.0029) and the log-additive (OR=0.40 (0.17-0.94), p=0.019) models. Findings. The results allow us to conclude that congenital genetic differences in the pathways of b-adrenoreception can be associated with the development of atrial fibrillation in patients with heart failure Author Biographies Sergiy Pyvovar, Government Institution “L. T. Malaya Therapy National Institute of the National Academy of Medical Sciences of Ukraine” Maloi L. ave., 2 a, Kharkiv, Ukraine, 61039 PhD, Senior Researcher Department of Clinical Pharmacology and Pharmacogenetics non Infective Diseases

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