Özet:

Objectives: Coronary artery disease (CAD) due to atherosclerosis is an important and common cause of mortality and morbidity in patients with diabetes mellitus (DM) and prediabetes. Endothelial dysfunction is a possible reason for the increased atherosclerosis in patients with diabetes. Previous studies have shown that hyperglycemia deteriorates endothelial functions, but there are not many studies have been conducted to investigate the acute effect of blood sugar regulation on impaired endothelial functions in patients with diabetes. So in this study, we evaluated the acute effect of blood sugar regulation with insulin infusion on endothelial functions in patients with diabetes. Materials and Methods: Forty-four patients with diabetes who were planned to start insulin infusion and 20 healthy individuals of similar age and gender were included in this study. Flow-mediated dilatation (FMD) method was used to evaluate endothelial functions. FMD values before and after insulin infusion in patients with diabetes were calculated and compared with those in the patient population and the healthy control group. Results: The mean age of the patients was 54.9±13.6 years and 54.5% were female. When the hyperglycemic and the normoglycemic periods were compared among themselves, FMD measured in the normoglycemic period was found to be significantly higher (6.13±3.11 vs 10.89±3.65, p<0.001). The FMD value in the group with diabetes was found to be significantly lower than that in the control group, even after treatment (10.89±3.65 vs 12.84±1.86, p<0.006). Conclusion: In type 2 patients with DM, endothelial functions are impaired during periods of hyperglycemia. Although endothelial functions improved in the acute period after blood sugar regulation, endothelial functions still continue to be impaired compared with the healthy control group. Patients with diabetes may be at higher risk of vascular events during hyperglycemic periods than in normoglycemic periods.

Anahtar Kelimeler: